Results 131 to 140 of about 43,204 (229)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Desmin characteristics of CD11b-positive fibers after eccentric contractions

, 2002
PURPOSE: The purpose of this study was to determine the desmin characteristics of fibers infiltrated by CD11b-leukocytes in fast- and slow-twitch murine muscles after eccentric contractions.
St Pierre Schneider, Barbara, Sannes, Heather, Fine, Jason, SCHNEIDER, Barbara St, Best, Thomas, Schneider, Barbara St. Pierre   +5 more
core   +1 more source

New Observations on a Low‐Grade Diffusely Infiltrative Tumour, SMARCB1 Mutant, Arguing for a New Tumour Type

Neuropathology and Applied Neurobiology, Volume 52, Issue 5, October 2026.
Two new cases of low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1 mutant, are described in an 18‐year‐old and a 50‐year‐old male, both with supratentorial lesions, characteristic rhabdoid histology on a myxoid‐collagenous background, and complete INI1 loss.
Alice Métais, Giorgia Antonia Simboli, Marc Barritault, Fabrice Chrétien, Julien Masliah‐Planchon, Alessandro Moiraghi, Johan Pallud, Laure Thomas, Pierre Leblond, Alexandre Bani‐Sadr, Raphaël Saffroy, Arnault Tauziède‐Espariat, Alexandre Vasiljevic, Pascale Varlet   +13 more
wiley   +1 more source

Orphan disease: features of difficult to diagnose and genetically verified muscular dystrophy based on DNA sequencing results (clinical case)

Acta Biomedica Scientifica
Currently, orphan diseases are rarely diagnosed due to low patient awareness, heterogeneity of symptoms, low publication activity of specialists who may encounter orphan pathology, and limited availability of molecular genetic technologies for verifying ...
Yu. I. Kotsenko
doaj   +1 more source

Über die Rolle von Desmin bei der Entwicklung von Herzzellen [PDF]

, 2011
Desmin ist ein Typ III Intermediär Filament Protein, das bisher vorallem für seine Funktion in der Erhaltung der zellulären Integrität von Muskelzellen bekannt war. Das Protein ist von enormer Bedeutung in der Regeneration von Muskelzellen nach Belastung,
Gawlas, Sonja
core  

Kinetics of desmin mutant aggregation.

, 2015
(A) C2C12 murine myoblasts transiently transfected with an expression vector coding for a GFP-tagged desmin mutant D399Y were fixed at various times (4 to 80 h) following transfection.
Eva Cabet (791303), Patrick Vicart (465398), Blandine Gausserès (5665093), Alain Lilienbaum (791304), Sabrina Batonnet-Pichon (265752), Florence Delort (465393)   +5 more
core   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Desmin-p.L112Q Disturbs Filament Formation and Is a Likely-Pathogenic Variant Associated with Dilated Cardiomyopathy

Journal of Cardiovascular Development and Disease
DES encodes the muscle-specific intermediate filament protein desmin, which is highly relevant to the structural integrity of cardiomyocytes. Mutations in this gene cause different cardiomyopathies including dilated cardiomyopathy.
Alexander Lütkemeyer, Sabrina Voß, Jonas Reckmann, Joline Groß, Anna Gärtner, Jan Gummert, Hendrik Milting, Andreas Brodehl   +7 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Using targeted proteomics to examine desmin regulation during C2C12 myogenesis

, 2013
Desmin is a type III intermediate filament protein found in the cytoskeleton of skeletal muscle. Mutations in the gene encoding for desmin has been shown to cause early onset cardio myopathy and extreme muscle weakness.
Palmer, Aunaly
core   +1 more source