Results 161 to 170 of about 43,204 (229)

Zea mays Drought‐Overly Sensitive1/TUBA4 Is Wilty3, and Transcriptome Co‐Expression Analysis of Shoot Meristem Mutant Tissues Reveals Wilty2/TUB6:Wi3 Interactions Associated With Stem Vascular Bundle Development

open access: yesPlant Direct, Volume 10, Issue 9, September 2026.
ABSTRACT Plant vasculature is essential for the transport of water, nutrients, and signaling molecules across organs, while also providing critical mechanical support for growth and development. Disruptions in vascular bundle formation can therefore lead to severe physiological and developmental defects.
Anuradha Dhingra   +2 more
wiley   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

open access: yesPROTEOMICS, Volume 26, Issue 9, Page 6-23, September 2026.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling   +6 more
wiley   +1 more source

Sustained Activation of CaMKII Promotes Skeletal Muscle Contractile Dysfunction in Aging

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
CaMKII exemplifies antagonistic pleiotropy in skeletal muscle. Exercise‐related Ca2+/redox signals drive transient CaMKII activation supporting youthful performance. Here we show CaMKII is upregulated in aged muscle, where dysregulated Ca2+/redox signals likely sustain its activity; constitutively active CaMKII recapitulates aging‐associated ...
Michael R. Bene   +15 more
wiley   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth   +14 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

open access: yesThe FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch   +2 more
wiley   +1 more source

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