Results 31 to 40 of about 18,110 (202)

Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Cell Death Discovery, 2021
Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates
Marion Bouvet, Emilie Dubois-Deruy, Annie Turkieh, Paul Mulder, Victoriane Peugnet, Maggy Chwastyniak, Olivia Beseme, Arthur Dechaumes, Philippe Amouyel, Vincent Richard, Nicolas Lamblin, Florence Pinet   +11 more
doaj   +1 more source

On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria [PDF]

Human Molecular Genetics, 2003
Recent studies in desmin (-/-) mice have shown that the targeted ablation of desmin leads to pathological changes of the extrasarcomeric intermediate filament cytoskeleton, as well as structural and functional abnormalities of mitochondria in striated muscle. Here, we report on a novel heterozygous single adenine insertion mutation (c.5141_5143insA) in
Rolf, Schröder, Bertrand, Goudeau, Monique Casteras, Simon, Dirk, Fischer, Thomas, Eggermann, Christoph S, Clemen, Zhenlin, Li, Jens, Reimann, Zhigang, Xue, Sabine, Rudnik-Schöneborn, Klaus, Zerres, Peter F M, van der Ven, Dieter O, Fürst, Wolfram S, Kunz, Patrick, Vicart   +14 more
openaire   +4 more sources

The cytoskeleton of the electric tissue of Electrophorus electricus, L.

Anais da Academia Brasileira de Ciências, 2000
The electric eel Electrophorus electricus is a fresh water teleost showing an electrogenic tissue that produces electric discharges. This electrogenic tissue is distributed in three well-defined electric organs which may be found symmetrically along both
CLAUDIA DOS SANTOS MERMELSTEIN, MANOEL LUIS COSTA, VIVALDO MOURA NETO   +2 more
doaj   +1 more source

Immunocytochemical characteristics of submucosal uterine myomas [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. Myomas of the uterus, the most common benign tumors, have been studied for decades from the aspects of different basic and clinical disciplines. Despite this fact, their pathogenesis is still poorly understood.
Mladenović-Mihailović Aleksandra, Mladenović-Bogdanović Zorica, Mitrović Predrag, Tanasković Irena, Ušaj-Knežević Slavica, Stanojević Marija   +5 more
doaj   +1 more source

Alveolar rhabdomyosarcoma in a dog confirmed using myogenin immunohistochemistry: a case report

Veterinární Medicína, 2016
A large mass from the right forelimb of a five-year-old, male, Maltese dog, was resected surgically and examined histopathologically. Grossly, the 4 × 6 cm mass was well-demarcated and firm.
J.K. Park, E.M. Lee, A.Y. Kim, E.J. Lee, I.H. Hong, M.R. Ki, K.S. Jeong   +6 more
doaj   +1 more source

Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1

Molecular Therapy: Nucleic Acids, 2023
Exon-skipping therapy is a promising treatment strategy for Duchenne muscular dystrophy (DMD), which is caused by loss-of-function mutations in the DMD gene encoding dystrophin, leading to progressive cardiomyopathy. In-frame deletion of exons 3–9 (Δ3–9),
Naoko Shiba, Xiao Yang, Mitsuto Sato, Shin Kadota, Yota Suzuki, Masahiro Agata, Kohei Nagamine, Masaki Izumi, Yusuke Honda, Tomoya Koganehira, Hideki Kobayashi, Hajime Ichimura, Shinichiro Chuma, Junichi Nakai, Shugo Tohyama, Keiichi Fukuda, Daigo Miyazaki, Akinori Nakamura, Yuji Shiba   +18 more
doaj   +1 more source

Pregnancy in Desmin-Related Cardiomyopathy [PDF]

American Journal of Perinatology Reports, 2015
The course of desmin-related restrictive cardiomyopathy (DRCM) during pregnancy has not been described previously because of the rarity of the condition. Following an episode of heart failure antecedent to conception, a 28-year-old primigravida with DRCM presented to establish prenatal care during the first trimester. Prenatal management consisted of β-
Arij Faksh, Elisabeth Codsi, Michel K. Barsoum, Brian C. Brost   +3 more
openaire   +3 more sources

Desmin and CD31 immunolabeling for detecting venous invasion of the pancreatobiliary tract cancers.

PLoS ONE, 2020
Although venous invasion (VI) is a poor prognostic factor for patients with pancreatobiliary tract cancers, its histopathologic characteristics have not been well described.
Junyoung Shin, Laura D Wood, Ralph H Hruban, Seung-Mo Hong   +3 more
doaj   +1 more source

Ovarian Leiomyoma Along with Uterine Leiomyomata: A Common Tumour at an Uncommon Site [PDF]

Journal of Clinical and Diagnostic Research, 2015
Ovarian leiomyoma is one of the rarest benign tumours of the ovary, mostly seen in women of reproductive age group. Here we report a case of ovarian leiomyoma as an incidental finding in a patient of 38-year-old woman with uterine leiomyomata ...
Indira Gunasekaran, Manjiri Phansalkar, Lal Bahadur Palo, Renu G'Boy Varghese   +3 more
doaj   +1 more source

Rare Case of Symptomatic Ovarian Leiomyoma in Perimenopausal Woman [PDF]

Journal of Clinical and Diagnostic Research, 2019
Leiomyoma is a very rare benign tumour to be found in ovary. Here, we report a case of 40-year-old perimenopausal women with large left ovarian mass. The Computerised Tomography (CT) showed left ovarian solid mass without ascites, right ovary was normal.
Vaibhav Kanti, Vandana Verma, Savita Agarwal   +2 more
doaj   +1 more source