Results 41 to 50 of about 18,110 (202)

Ubiquitin-specific peptidase 8 regulates proliferation and early differentiation of sheep skeletal muscle satellite cells

Czech Journal of Animal Science, 2021
Ubiquitin-specific protease 8 (USP8), a member of the ubiquitin-specific protease (USP) family, was originally identified as playing a role in the regulation of growth and cell cycle. However, its functional role in myogenesis is unknown.
Shaoyu Wang, Kui Li, Hui Gao, Zepeng Liu, Shuang Shi, Qiang Tan, Zhengguang Wang   +6 more
doaj   +1 more source

Desmin-related restrictive cardiomyopathy in a pediatric patient: A case report

Indian Journal of Pathology and Microbiology, 2013
Restrictive cardiomyopathies in the pediatric population have diverse etiologies, including storage diseases like hemosiderosis, glycogenoses and desmin with its associated proteins.
Shruti Sharma, Rajnish Juneja, Gautam Sharma, Sudheer Arava, Ruma Ray   +4 more
doaj   +1 more source

Nasal leiomyosarcoma in a Quarter Horse

Ciência Rural, 2022
: We described the clinical and anatomopathological findings observed in a case of nasal leiomyosarcoma in a five-year-old male Quarter Mile horse, whose main complaints were decreased sports performance and bilateral purulent nasal discharge. The nodule
Millena de Oliveira Firmino, Rodrigo Cruz Alves, Yanca Góes dos Santos Soares, Rodolfo Monteiro Bastos, Daniel Medeiros de Assis, Deborah Castro, Glauco José Nogueira de Galiza, Antônio Flávio Medeiros Dantas   +7 more
doaj   +1 more source

Noncompaction cardiomyopathy is caused by a novel in‐frame desmin (DES) deletion mutation within the 1A coiled‐coil rod segment leading to a severe filament assembly defect

Human Mutation, 2019
Mutations in DES, encoding desmin protein, are associated with different kinds of skeletal and/or cardiac myopathies. However, it is unknown, whether DES mutations are associated with left ventricular hypertrabeculation (LVHT).
A. Marakhonov, A. Brodehl, R. Myasnikov, P. Sparber, A. Kiseleva, O. Kulikova, A. Meshkov, A. Zharikova, S. Koretsky, M. Kharlap, C. Stanasiuk, E. Mershina, V. Sinitsyn, A. Shevchenko, N. Mozheyko, O. M. Drapkina, S. Boytsov, H. Milting, M. Skoblov   +18 more
semanticscholar   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Desmin gene expression is not ubiquitous in all upper airway myofibers and the pattern differs between healthy and sleep apnea subjects

European Journal of Medical Research
Background Desmin is a major cytoskeletal protein considered ubiquitous in mature muscle fibers. However, we earlier reported that a subgroup of muscle fibers in the soft palate of healthy subjects and obstructive sleep apnea patients (OSA) lacked ...
Per Stål, Hanna Nord, Jonas von Hofsten, Thorbjörn Holmlund, Farhan Shah   +4 more
doaj   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Thioflavin T in-gel staining for ex vivo analysis of cardiac amyloid

Frontiers in Molecular Biosciences
There are limited options to quantify and characterize amyloid species from biological samples in a simple manner. Thioflavin T (ThT) has been used for decades to stain amyloid fibrils, but to our knowledge, we were the first to use it in-gel. Thioflavin
Joseph Oldam, Irina Tchernyshyov, Jennifer Van Eyk, Juan Troncoso, Charles G. Glabe, Giulio Agnetti, Giulio Agnetti   +6 more
doaj   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy

Journal of Cell Biology, 2018
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of aging and disease. We demonstrated that myofibril loss requires depolymerization of the desmin cytoskeleton, which is activated by phosphorylation. Here, we developed a
Dina Aweida, Inga Rudesky, A. Volodin, E. Shimko, Shenhav Cohen   +4 more
semanticscholar   +1 more source