Results 11 to 20 of about 6,762 (204)
Desmoplakin interacts with the coil 1 of different types of intermediate filament proteins and displays high affinity for assembled intermediate filaments. [PDF]
PLoS ONE, 2018 The interaction of intermediate filaments (IFs) with the cell-cell adhesion complexes desmosomes is crucial for cytoskeletal organization and cell resilience in the epidermis and heart.
Bertrand Favre +6 more
doaj +4 more sources
Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. [PDF]
PLoS Genetics, 2010 We used the RIP1-Tag2 (RT2) mouse model of islet cell carcinogenesis to profile the transcriptome of pancreatic neuroendocrine tumors (PNET) that were either non-invasive or highly invasive, seeking to identify pro- and anti-invasive molecules ...
Matthew G H Chun, Douglas Hanahan
doaj +4 more sources
Desmoplakin cardiomyopathy: case report
European Heart Journal - Case ReportsAbstract Background Desmoplakin (DSP) cardiomyopathy is a distinct form of cardiomyopathy characterized by frequent left ventricular involvement with extensive fibrosis, high arrhythmic risk, and episodes of acute myocardial injury. Case summary
Ayman Helal +3 more
openaire +3 more sources
Actomyosin forces trigger a conformational change in desmoplakin within desmosomes
Nature CommunicationsDesmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong +6 more
doaj +2 more sources
Cardiac Complications of Pregnancy in Desmoplakin Cardiomyopathy
JACC: Case Reports, 2023 We present the course of 4 pregnancies in 3 women with desmoplakin cardiomyopathy, with a focus on changes in left ventricular ejection fraction and N-terminal pro–B-type natriuretic peptide levels from the prepregnancy period through the postpartum ...
Madeline E. Duncan, BS +4 more
doaj +3 more sources
Molecular Genetics and Metabolism Reports, 2016 Background: Carvajal syndrome is an autosomal dominant or autosomal recessive disorder, manifesting with dilated cardiomyopathy, woolly hair, and palmoplantar keratoma. Additional manifestations can be occasionally found.
Josef Finsterer +4 more
doaj +2 more sources
Desmoplakin Loss Leads to PKC- and Src-Mediated Contractile Dysfunction in Cardiomyocytes. [PDF]
Circ ResBACKGROUND: Mutations in DSP , which encodes the protein desmoplakin, lead to cardiomyopathy with unusually high penetrance that presents with ...
Gokhan I +9 more
europepmc +2 more sources
Frontiers in Cardiovascular Medicine, 2023 BackgroundPathogenic/Likely pathogenic variants in DSP-encoded desmoplakin are strongly associated with arrhythmogenic cardiomyopathy (ACM). However, their contribution towards sinus node dysfunction has not been well-delineated.Case summaryA 74-year-old
Nicholas Y. Tan +4 more
doaj +1 more source
Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs
Anatolian Journal of Cardiology, 2023 Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang +6 more
doaj +1 more source
Cortical tension regulates desmosomal morphogenesis
Frontiers in Cell and Developmental Biology, 2022 Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch +2 more
doaj +1 more source