Results 81 to 90 of about 6,762 (204)

Single Cell Mechanics in Disease Progression

Small Science, Volume 6, Issue 7, July 2026.
Cells transmit distinct mechanical forces through ECM adhesion and cell–cell junctions and actomyosin‐generated traction forces are transmitted to the substrate through integrin‐based focal adhesions. Mechanical signals are further transmitted to the nucleus via the LINC complex, connecting the cytoskeleton to the nuclear lamina. These forces integrate
Sabin Kim, Jongmin Lee, Kyungtae Lim, Dong‐Hwee Kim   +3 more
wiley   +1 more source

Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases

Scientific Reports
Arrhythmogenic cardiomyopathy (AC) is a common cause of sudden cardiac arrest and death in young adults. It can be induced by different types of mutations throughout the desmoplakin gene including the R2834H mutation in the extreme carboxyterminus tail ...
Cedric Badowski, Paula Benny, Chandra S. Verma, E. Birgitte Lane   +3 more
doaj   +1 more source

Desmoplakin’s tail gets the message [PDF]

Journal of Cell Biology, 2015
![Figure][1] Desmoplakin (green) normally resides at cell–cell junctions (top), but in cells that can’t methylate its tail (bottom), it gathers along intermediate filaments (red). Cells control the junction protein desmoplakin by methylating and phosphorylating its tail, [Albrecht ...
openaire   +1 more source

Autoantibodies in Patients With Arrhythmogenic Cardiomyopathy Activate GSK‐3β, Resulting in a Loss of Cardiomyocyte Cohesion

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Background Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac desmosome disease, as more than 50% of affected patients carry pathogenic variants in desmosome protein‐coding genes. In this study, we focused on the role and mechanisms of pathogenic and non‐pathogenic autoantibodies against intercalated disc (ICD) proteins such as ...
Soumyata Pathak, Konstanze Stangner, Ellen Kempf, Sina Moztarzadeh, Matthias Hiermaier, Stephanie Wider, Marlene Rauschmayer, Tatjana Williams, Andreas Stengl, Brenda Gerull, Ruth Biller, Sebastian Clauss, Stefan Kääb, Tomo Šarić, Sunil Yeruva, Jens Waschke   +15 more
wiley   +1 more source

Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study [PDF]

, 2012
Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated
Asimaki, A, Syrris, P, Tinker, Andrew, McKenna, William J., Nobles, M, Saffitz, Jeffrey E., Chaubey, S, Saffitz, JE, Ahmed, AK, Ciaccio, Edward J., Quarta, G, Gomes, John, Asimaki, Angeliki, Ciaccio, EJ, McKenna, WJ, Finlay, Malcolm, Gomes, J, Lambiase, PD, Lambiase, Pier D., Nobles, Muriel, Syrris, Petros, Chaubey, Sanjay, Ahmed, Akbar K., Finlay, M, Tinker, A, Quarta, Giovanni   +25 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Diminution of R‐Loops Generated by LncRNA DSP‐AS1 Inhibits DSP Gene Transcription to Impede the Re‐Epithelialization During Diabetic Wound Healing

Advanced Science
Re‐epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms in the context of diabetic wounds remain elusive.
Chen Yang, Hong Lian, Hengli Luo, Chenlin Song, Jianghong Lin, Zhuoxian Liang, Yulin Yang, Xiaosi Hong, Shaohua Li, Yanbo Chen, Liangyan Wu, Li Yan, Sifan Chen, Meng Ren   +13 more
doaj   +1 more source

Desmoplakin I and desmoplakin II. Purification and characterization.

The Journal of biological chemistry, 1989
Desmoplakins I and II (DP1 and DP2), major cytoskeletal structural proteins concentrated in desmosomes, have been purified in milligram quantities from keratomed pig tongue epithelium. DP1 and DP2 extracted from purified desmosomes in 4 M urea were chromatographed on DEAE-cellulose and remained soluble after removal of urea during subsequent ...
E J, O'Keefe, H P, Erickson, V, Bennett
openaire   +1 more source

ECMO Support in Paraneoplastic Pemphigus With Respiratory Failure: A Case Report With Immune Cell Monitoring

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Paraneoplastic pemphigus (PNP) is a life‐threatening autoimmune blistering disease with a mortality rate of 70%–90%, driven largely by respiratory complications such as bronchiolitis obliterans. Managing respiratory failure in these patients remains exceptionally difficult.
Lu Li, Danxia Chen, Linzi Jin, Qinqin Shu, Juan He, Yan Li   +5 more
wiley   +1 more source

The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations

, 2011
Desmoplakin is a cytoplasmic desmosomal protein that plays a vital role in normal intercellular adhesion. Mutations in desmoplakin can result in devastating skin blistering diseases and arrhythmogenic right ventricular cardiomyopathy, a heart muscle ...
Jeeves, Mark, Behr, Elijah, Timothy Knowles, Knowles, Timothy; id_orcid, Behr, E, Al-Jassar, Caezar, Kami, K, Caezar Al-Jassar, Mark Jeeves, Martyn Chidgey, Keiichiro Kami, Bikker, Hennie, Chidgey, Martyn, Bikker, H, Kami, Keiichiro, Hennie Bikker, Overduin, Michael, Elijah Behr, Knowles, Timothy, Michael Overduin   +19 more
core   +1 more source