Results 101 to 110 of about 6,762 (204)

Red Flags for Differentiating Desmosomal “Hot‐Phase” Cardiomyopathy From Acute Myocarditis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Desmosomal “hot‐phase” cardiomyopathy (HPC), characterized by bursts of myocardial inflammation mimicking acute myocarditis (AM), carries relevant risks of adverse outcomes. This study aimed to identify diagnostic “red flags” favoring HPC over
Giovanni Peretto, Nicolas Piriou, Alessio Gasperetti, Barbara Bauce, Andrea Villatore, Alessia F. Trezza, Alex Melot, Anna Palmisano, Giulia Bassetto, Marika Martini, Chiara Di Resta, Cinzia Radesich, Alessia Paldino, Maria Perotto, Eric D. Smith, Michele Ciabatti, Elisa Bruno, Monica De Gaspari, Stefania Rizzo, Kalliopi Pilichou, Antonio Esposito, Leonardo Calò, Maurizio Pieroni, Gianfranco Sinagra, Cristina Basso, Adam Helms, Paolo Della Bella, Marco Merlo   +27 more
doaj   +1 more source

Ventricular Tachycardia Ablation in Patients With Desmoplakin Cardiomyopathy

JACC: Clinical Electrophysiology
Desmoplakin (DSP) pathogenic variants are rare causes of arrhythmogenic cardiomyopathy and often involve the right and left ventricles. Ventricular tachycardia (VT) ablations may be required in these patients, but procedural characteristics have not been reported.In this study, the authors sought to report a multicenter experience of VT ablation in ...
Ghannam, M., Liang, J.J., Hoogendoorn, J., Zeppenfeld, K., Siontis, K.C., Asirvatham, S.J., Sacher, F., Maury, P., Gandjbakhch, E., Morady, F., Bogun, F.   +10 more
openaire   +3 more sources

Structure of the Intermediate Filament-Binding Region of Desmoplakin

PLOS ONE, 2016
Desmoplakin (DP) is a cytoskeletal linker protein that connects the desmosomal cadherin/plakoglobin/plakophilin complex to intermediate filaments (IFs). The C-terminal region of DP (DPCT) mediates IF binding, and contains three plakin repeat domains (PRDs), termed PRD-A, PRD-B and PRD-C. Previous crystal structures of PRDs B and C revealed that each is
Hyunook Kang, Thomas M Weiss, Injin Bang, William I Weis, Hee-Jung Choi   +4 more
openaire   +4 more sources

Case report : desmoplakin cardiomyopathy presenting as an inflammatory cardiomyopathy with repeated sudden cardiac arrests

Background: Desmoplakin cardiomyopathy has been recently classified as a non-dilated left ventricular cardiomyopathy, which is characterized by inflammatory-like episodes followed by left ventricular fibrosis/dysfunction and ventricular arrhythmias ...
Fokstuen, Siv, Dominati, Arnaud, Suchet, Sebastian, Carballo, David Andrés, Meyer, Philippe, Hervier, Elsa, Massie, Emmanuelle, Seebach, Jorg Dieter   +7 more
core   +1 more source

The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy

JACC: Advances
Background: Electrocardiographic findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) have been limited to small studies. Objectives: The authors aimed to analyze the electrocardiogram (ECG) characteristics of ALVC, to correlate ECG with ...
Leonardo Calò, MD, Cinzia Crescenzi, MD, Andrea Di Marco, MD, PhD, Francesca Fanisio, MD, Fabiana Romeo, MD, Alessio Gargaro, MSc, Annamaria Martino, MD, PhD, Chiara Cappelletto, MD, Marco Merlo, MD, Mattia Targetti, MD, Elisabetta Toso, MD, Federica Toto, MD, Maria Beatrice Musumeci, MD, Giacomo Tini, MD, Michele Ciabatti, MD, Matteo Stefanini, MD, Stefano Canestrelli, MD, Elisa Fedele, MD, Chiara Lanzillo, MD, PhD, Armando Fusco, MD, PhD, Federica Carla Sangiuolo, MD, PhD, Cinzia Radesich, MD, Maria Perotto, MD, Maurizio Pieroni, MD, Ruggiero Mango, MD, PhD, Alessio Gasperetti, MD, PhD, Camillo Autore, MD, Michela Casella, MD, PhD, Antonio Dello Russo, MD, PhD, Davide Stolfo, MD, PhD, Mikael Laredo, MD, PhD, Estelle Gandjbakhch, MD, PhD, Maddalena Graziosi, MD, PhD, Elena Biagini, MD, PhD, Costantina Catalano, MD, Ludovica Barile, MD, Fabrizio Drago, MD, Marianna Cicenia, MD, Anwar Baban, MD, PhD, Gemma Pelargonio, MD, PhD, Maria Lucia Narducci, MD, Federica Re, MD, Giovanni Peretto, MD, Elena Paiotti, MD, Carles Diez Lopez, MD, Iacopo Olivotto, MD, Fiorenzo Gaita, MD, Gianfranco Sinagra, MD, Giuseppe Novelli, MD, PhD   +48 more
doaj   +1 more source

A case of arrhythmic cardiomyopathy caused by rare multiple gene mutations

Frontiers in Cardiovascular Medicine
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized by a high risk of ventricular tachycardia and sudden cardiac death, often involving the right ventricle or both ventricles, with the initial onset usually in adolescence or ...
Kaiqin Liang, Hong Wang, Minfang Wu, Meng Cui, Kaiyou Liu, Mintao Gan, Wengong Cheng, Aiqiong Huang   +7 more
doaj   +1 more source

Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin.

PLoS ONE, 2013
Envoplakin, periplakin and desmoplakin are cytoskeletal proteins that provide structural integrity within the skin and heart by resisting shear forces. Here we reveal the nature of unique hinges within their plakin domains that provides divergent degrees
Caezar Al-Jassar, Pau Bernadό, Martyn Chidgey, Michael Overduin   +3 more
doaj   +1 more source

Mechanical loading of desmosomes depends on the magnitude and orientation of external stress

Nature Communications, 2018
Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J. Price, Anna-Lena Cost, Hanna Ungewiß, Jens Waschke, Alexander R. Dunn, Carsten Grashoff   +5 more
doaj   +1 more source

Desmoplakin Regulates Desmosome Hyperadhesion [PDF]

Journal of Investigative Dermatology, 2012
Hobbs, Ryan P., Green, Kathleen J.
openaire   +2 more sources

A novel desmoplakin mutation associated with left dominant arrhythmogenic cardiomyopathy and cutaneous phenotype

Hellenic Journal of Cardiology, 2021
Georgios Efthimiadis, Thomas Zegkos, Soultana Meditskou, Theodoros Karamitsos, Emmanouil Manolakos, Ioannis Papoulidis, Sandro Orru, C. Cadeddu Dessalvi, Haralambos Karvounis, Despoina Parcharidou   +9 more
doaj   +1 more source