Plasma desmosine for prediction of outcomes after acute myocardial infarction [PDF]
Frontiers in Cardiovascular Medicine, 2022 BackgroundElastin degradation is implicated in the pathology of vulnerable plaque. Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes.
Kashan Ali +9 more
doaj +7 more sources
Desmosine: The Rationale for Its Use as a Biomarker of Therapeutic Efficacy in the Treatment of Pulmonary Emphysema [PDF]
DiagnosticsDesmosine and isodesmosine (DID) are elastin-specific crosslinking amino acids that play a critical role in maintaining the structural integrity of elastic fibers, and their levels in body fluids may serve as biomarkers for alveolar wall injury.
Jerome Cantor
doaj +4 more sources
Plasma Desmosine and Abdominal Aortic Aneurysm Disease [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation and ...
Ify R. Mordi +12 more
doaj +9 more sources
Desmosine as a biomarker for the emergent properties of pulmonary emphysema [PDF]
Frontiers in Medicine, 2023 Developing an effective treatment for pulmonary emphysema will require a better understanding of the molecular changes responsible for distention and rupture of alveolar walls.
Jerome Cantor
doaj +4 more sources
Evaluation of dry eye syndrome in patients with obstructive sleep apnea syndrome based on serum hypoxia-inducible factor 1 alpha (HIF-1α), matrix metalloproteinase 2 (MMP-2), and desmosine levels [PDF]
BMC OphthalmologyPurpose To determine changes in dry eye parameters and serum HIF-1α, MMP-2, and desmosine levels in obstructive sleep apnea syndrome (OSAS) and their correlation.
Murat Okutucu +8 more
doaj +4 more sources
Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD [PDF]
ERJ Open Research, 2020 Background Vitamin D supplementation lowers exacerbation frequency in severe vitamin D-deficient patients with COPD. Data regarding the effect of vitamin D on elastin degradation are lacking.
Rob Janssen +8 more
doaj +2 more sources
Case Report: Contrasting outcomes and use of desmosine to monitor two patients treated with plasma cell-directed chemotherapy for gammopathy-driven pulmonary elastolysis in acquired cutis laxa [PDF]
Frontiers in HematologyAcquired cutis laxa (ACL) is a rare connective tissue disorder that is characterised by loose, pendulous skin and can be associated with systemic elastolysis and plasma cell dyscrasias (PCD).
Lydia Lee +8 more
doaj +2 more sources
Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD [PDF]
, 2016 Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation.
Agustí, Alvar +19 more
core +9 more sources
The Competitive Interaction of Alveolar Wall Distention with Elastin Crosslinking: A Mechanistic Approach to Emergent Phenomena in Pulmonary Emphysema [PDF]
CellsEmergent phenomena arise from the interaction of competing forces at multiple scale levels, resulting in complex outcomes that are not readily apparent from analyzing the individual components.
Jerome Cantor
doaj +2 more sources
Elastin Peptides as a Potential Disease Vector in the Pathogenesis of Pulmonary Emphysema: An Investigation of This Hypothesis [PDF]
LifeThe degradation of elastic fibers is a fundamental characteristic of pulmonary emphysema, resulting in the release of proinflammatory elastin peptides.
Jerome Cantor
doaj +2 more sources