Desmosine as a biomarker for the emergent properties of pulmonary emphysema [PDF]
Frontiers in Medicine, 2023 Developing an effective treatment for pulmonary emphysema will require a better understanding of the molecular changes responsible for distention and rupture of alveolar walls.
Jerome Cantor
doaj +7 more sources
Plasma Desmosine and Abdominal Aortic Aneurysm Disease [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation and ...
Ify R. Mordi +12 more
doaj +11 more sources
Ultraviolet radiation reduces desmosine cross-links in elastin
Biochemistry and Biophysics Reports, 2017 Elastic fibers, a major component of the extracellular matrix of the skin, are often exposed to ultraviolet (UV) radiation throughout mammalian life. We report on an in vitro study of the alterations in bovine nuchal ligament elastic fibers resulting ...
Basant Dhital +8 more
doaj +9 more sources
Desmosine: The Rationale for Its Use as a Biomarker of Therapeutic Efficacy in the Treatment of Pulmonary Emphysema [PDF]
DiagnosticsDesmosine and isodesmosine (DID) are elastin-specific crosslinking amino acids that play a critical role in maintaining the structural integrity of elastic fibers, and their levels in body fluids may serve as biomarkers for alveolar wall injury.
Jerome Cantor
doaj +4 more sources
High urinary desmosine is associated with long-term mortality in patients with COPD [PDF]
ERJ Open Research, 2023 COPD is the third most frequent cause of death worldwide and its global burden is predicted to increase further. Accurate prediction of mortality is important because it helps identify patients for whom the implementation of therapeutic measures can ...
Changhwan Kim +11 more
doaj +5 more sources
Plasma desmosine for prediction of outcomes after acute myocardial infarction [PDF]
Frontiers in Cardiovascular Medicine, 2022 BackgroundElastin degradation is implicated in the pathology of vulnerable plaque. Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes.
Kashan Ali +9 more
doaj +6 more sources
Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD [PDF]
European Respiratory Journal, 2016 Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation.
Roberto A Rabinovich +2 more
exaly +14 more sources
Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis [PDF]
Respiratory Research, 2018 Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in both lung diseases.
Bart de Brouwer +8 more
doaj +6 more sources
Serum Desmosine Levels Might Be Associated with the Size of Ruptured Cerebral Aneurysms in Patients with Aneurysmal Subarachnoid Hemorrhage-A Preliminary Study. [PDF]
J Clin MedBackground: Aneurysmal subarachnoid hemorrhage (aSAH) is a disease associated with high mortality, caused by the rupture of a cerebral aneurysm. Decision-support scoring systems used for managing unruptured aneurysms (UIAs) include only radiological ...
Csecsei P +5 more
europepmc +4 more sources
Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD [PDF]
ERJ Open Research, 2020 Background Vitamin D supplementation lowers exacerbation frequency in severe vitamin D-deficient patients with COPD. Data regarding the effect of vitamin D on elastin degradation are lacking.
Rob Janssen +8 more
doaj +3 more sources