Results 171 to 180 of about 3,049 (232)

The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease. [PDF]

Medicina (Kaunas)
Liu SF, Li CL, Lee HC, Chang HC, Liu JF, Kuo HC.   +5 more
europepmc   +1 more source

Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis. [PDF]

Cells
Lloyd SM, He Y.
europepmc   +1 more source

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Synthesis of Multi‐Deuterated Desmosine

ChemistrySelect, 2020
AbstractDesmosine, a crosslinking pyridinium amino acid found in elastin, is a useful biomarker for the diagnosis of diseases related to elastin degradation, such as chronic obstructive pulmonary disease (COPD). In order to achieve the precise quantitation of this compound using isotope dilution liquid chromatography‐tandem mass spectrometry (LC‐MS/MS)
Manoj Kumar Karnena, Toyonobu Usuki
exaly   +4 more sources

P6505Urinary desmosine, an elastin-specific degradation product is associated with maximum aortic root size and aortic z-scores in patients with bicuspid aortic valve

European Heart Journal, 2019
Bicuspid aortic valve (BAV) is the commonest congenital cardiac abnormality affecting up to 2% of the general population. BAV is highly diverse in phenotype however a common feature is its inherent risk of morbidity and mortality from aortic root ...
Zaid Iskandar, J. Huang, I. Mordi, L. Miller, C. Chin, D. Goudie, C. Mcwilliam, J. Berg, A. Neagoie, Chim C. Lang, A. Choy   +10 more
exaly   +2 more sources

Synthesis of Ser-Ala-Ala Cyclic Desmosine

Synthesis, 2023
Elastin is present in the extracellular matrix of various tissues, most abundantly in the aorta and major vascular vessels, and is formed by self-assembly followed by concomitant crosslinkers of tropoelastin, an elastin precursor.
Shogo Satoh, Daria Baut, Moena Hirao, Daisuke Watanabe, Rina Suzuki, Toyonobu Usuki   +5 more
semanticscholar   +1 more source

Free lung desmosine: a potential biomarker for elastic fiber injury in pulmonary emphysema

Biomarkers, 2022
Introduction Desmosine and isodesmosine (DID) are biomarkers for elastic fibre damage in pulmonary emphysema. However, current methods for measuring lung DID involve tissue hydrolysis and lack specificity for those fibres undergoing breakdown. To address
Michael Fagiola, George Gu, J. Avella, J. Cantor   +3 more
semanticscholar   +1 more source

Urine Desmosine as a Novel Biomarker for Bronchopulmonary Dysplasia and Postprematurity Respiratory Disease in Extremely Preterm or Low Birth Weight Infants

American Journal of Perinatology, 2022
Objective  This study aimed to evaluate whether elevated urine desmosine levels at 3 weeks of age were associated with severe radiological findings, bronchopulmonary dysplasia (BPD), and post-prematurity respiratory disease (PRD) in extremely preterm (EP)
K. Hirata, Masanori Nishikawa, M. Nozaki, H. Kitajima, I. Yanagihara, Kazuko Wada, M. Fujimura   +6 more
semanticscholar   +1 more source

Radioimmunoassay for Desmosine

Connective Tissue Research, 1980
A radioimmunoassay was developed for the determination of desmosine. Desmosine conjugated to albumin was injected into rabbits which developed useful titers of serum antibodies after six months. A radioactive probe was prepared with desmosine using [125I]-Bolton-Hunter reagent.
V. S. Mohan, Barry C. Starcher, G. S. King   +2 more
openaire   +3 more sources

Structure of Desmosine and Isodesmosine

Nature, 1966
IN 1963 Partridge, Elsden and Thomas1 reported the isolation of two new amino-acids named desmosino and isodesmosine from bovine ligamentum nuchae elastin. Since then the presence of these amino-acids has been demonstrated in elastins from various sources2.
R. A. Anwar, G. Oda
openaire   +3 more sources

The biosynthesis of desmosine and isodesmosine II. Incorporation of specifically labeled lysine into desmosine and isodesmosine

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1967
Abstract 1. 1.|The incorporation of radioactivity into desmosine and isodesmosine from [I- 14 C]lysine and [6- 14 C]lysine was studied using chick embryo aortae in tissue culture. 2. 2.|The side chain attached to the pyridinium nitrogen in desmosine and iso-desmosine was liberated in the form of lysine by the action of strong alkali. 3. 3.
G. Oda, R. A. Anwar
openaire   +3 more sources