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Ultraviolet radiation reduces desmosine cross-links in elastin

Biochemistry and Biophysics Reports, 2017
Elastic fibers, a major component of the extracellular matrix of the skin, are often exposed to ultraviolet (UV) radiation throughout mammalian life. We report on an in vitro study of the alterations in bovine nuchal ligament elastic fibers resulting ...
Basant Dhital +8 more
doaj +5 more sources

The effect of tiotropium therapy on markers of elastin degradation in COPD [PDF]

Respiratory Research, 2009
Background Desmosine and Isodesmosine (D/I) are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue elastase activity.
Tartell Lori +3 more
doaj +2 more sources

Study of blood desmosine level in patients with COPD exacerbation in relation to severity

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Desmosine (DES), a cross linking amino-acid unique to mature elastin is expected to increase in proportion to the recruitment and activation of the inflammatory cells induced by smoking, exposure to biomass fuel smoke etc., or during acute ...
Sayed Labib +3 more
doaj +2 more sources

Characteristics of alpha-1 antitrypsin deficiency related lung disease exacerbations using a daily symptom diary and urinary biomarkers. [PDF]

PLoS ONE
BackgroundPulmonary exacerbations in alpha-1 antitrypsin deficiency (AATD) related lung disease are a significant contributor to disease burden, as with usual COPD.
Paul Ellis +8 more
doaj +2 more sources

Serum Desmosine Levels Might Be Associated with the Size of Ruptured Cerebral Aneurysms in Patients with Aneurysmal Subarachnoid Hemorrhage-A Preliminary Study. [PDF]