Frontiers in HematologyAcquired cutis laxa (ACL) is a rare connective tissue disorder that is characterised by loose, pendulous skin and can be associated with systemic elastolysis and plasma cell dyscrasias (PCD).
Lydia Lee +8 more
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Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial [PDF]
ERJ Open Research, 2018 Elastin degradation in the lung, leading to emphysema, and elastin degradation in blood vessels, leading to atherosclerosis, are key mechanisms in the development and progression of chronic obstructive pulmonary disease (COPD) [1].
James D. Chalmers +7 more
doaj +5 more sources
BS7 Plasma desmosine as a biomarker in acute aortic syndrome [PDF]
Basic science, 2021 Introduction Acute aortic syndromes (AAS) include aortic dissection, intramural haematoma and penetrating aortic ulcer, all of which are caused by aortic wall failure and associated with significant mortality.
Maaz Syed +8 more
semanticscholar +4 more sources
Association between plasma desmosine, a marker of elastin degradation, and total atherosclerotic burden measured by whole body magnetic resonance angiography [PDF]
European Heart Journal, 2022 Elastin degradation has been implicated in the pathophysiology of vulnerable atherosclerotic plaque. Desmosine is the cross-link component in the elastin molecule and is exclusively released from mature elastin breakdown, thus has the potential to ...
Kamar Ali +8 more
openalex +2 more sources
Middle-Scale IsoChichibabin Desmosine Synthesis
Heterocycles, 2022 – Desmosine is a 1,3,4,5-tetrasubstituted pyridinium amino acid that crosslinks elastin, and is considered to be a useful biomarker for elastin-degraded diseases such as chronic obstructive pulmonary disease (COPD).
Toyonobu Usuki +3 more
openalex +2 more sources
The Competitive Interaction of Alveolar Wall Distention with Elastin Crosslinking: A Mechanistic Approach to Emergent Phenomena in Pulmonary Emphysema [PDF]
CellsEmergent phenomena arise from the interaction of competing forces at multiple scale levels, resulting in complex outcomes that are not readily apparent from analyzing the individual components.
Jerome Cantor
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Elastin Peptides as a Potential Disease Vector in the Pathogenesis of Pulmonary Emphysema: An Investigation of This Hypothesis [PDF]
LifeThe degradation of elastic fibers is a fundamental characteristic of pulmonary emphysema, resulting in the release of proinflammatory elastin peptides.
Jerome Cantor
doaj +2 more sources
Effects of Vitamin D and K on Interleukin-6 in COVID-19 [PDF]
Frontiers in Nutrition, 2022 BackgroundPathology during COVID-19 infection arises partly from an excessive inflammatory response with a key role for interleukin (IL)-6. Both vitamin D and K have been proposed as potential modulators of this process.MethodsWe assessed vitamin D and K
Margot P. J. Visser +7 more
doaj +2 more sources
The effect of tiotropium therapy on markers of elastin degradation in COPD [PDF]
Respiratory Research, 2009 Background Desmosine and Isodesmosine (D/I) are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue elastase activity.
Tartell Lori +3 more
doaj +2 more sources