Biosynthetic pathway of desmosines in elastin [PDF]
Biochemical Journal, 1973 1. Elastins purified by various methods from the ligamentum nuchae and the lungs of cattle of various ages were analysed for amino acid compositions and lysine-derived cross-links. 2. In fully mature elastins from adults the main cross-links were desmosine, isodesmosine and lysinonorleucine and the so-called aldol-condensation product. Trace amounts of
G. E. Francis +2 more
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The Biosynthesis of Desmosine and Isodesmosine
Journal of Biological Chemistry, 1966 The biosynthesis of desmosine and isodesmosine was studied with chick embryo aortas in tissue culture. Radioactivity was incorporated into desmosine and isodesmosine when uniformly labeled lysine-14C was added to the medium, but no activity could be incorporated into these amino acids from aspartic acid-14C, glutamic acid-14C, or threonine-14C.
R. A. Anwar, George Oda
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Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial [PDF]
ERJ Open Research, 2018 James D. Chalmers +7 more
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A structural model for desmosine cross-linked peptides [PDF]
Biochemical Journal, 1978 Desmosine-enriched peptides were isolated from a thermolysin digest of bovine ligamentum nuchae elastin and a partial sequence was determined. A ‘two-cross-link’ model is proposed in which a second cross-link, perhaps lysinonorleucine, joins two peptide chains approx. 35 amino acid residues removed from the desmosine. Implied in this model is a certain
Robert P. Mecham, J.A. Foster
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Desmosine-Inspired Cross-Linkers for Hyaluronan Hydrogels [PDF]
Scientific Reports, 2013 We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones.
Valentin Hagel +14 more
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Middle-Scale IsoChichibabin Desmosine Synthesis [PDF]
HETEROCYCLES, 2022 Toyonobu Usuki +3 more
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Correlation between LC-MS/MS and ELISA methods for quantitative analysis of desmosine-containing solutions. [PDF]
BioanalysisAraki A +5 more
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Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair. [PDF]
Adv Sci (Weinh)MMS/MSCE/CAT is a dual‐driven nanomotor, guided by magnetic fields to accumulate in low‐flow regions near arterial walls and subsequently targets abdominal aortic aneurysms (AAAs) via chemotaxis. This improves the delivery efficiency of mesenchymal stem cell exosomes and promotes elastic matrix regeneration repair, reversing AAA progression through ...
Wang L, Zhang Y, Mao C, Li X.
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Serum desmosine levels are associated with the size of ruptured cerebral aneurysms in patients with aneurysmal subarachnoid hemorrhage [PDF]
Csecsei P +5 more
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Effects of Vitamin D and K on Interleukin-6 in COVID-19
Frontiers in Nutrition, 2022 BackgroundPathology during COVID-19 infection arises partly from an excessive inflammatory response with a key role for interleukin (IL)-6. Both vitamin D and K have been proposed as potential modulators of this process.MethodsWe assessed vitamin D and K
Margot P. J. Visser +7 more
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