Study of blood desmosine level in patients with COPD exacerbation in relation to severity
Egyptian Journal of Chest Disease and Tuberculosis, 2014 Background: Desmosine (DES), a cross linking amino-acid unique to mature elastin is expected to increase in proportion to the recruitment and activation of the inflammatory cells induced by smoking, exposure to biomass fuel smoke etc., or during acute ...
Sayed Labib +3 more
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Exaggerated elastin turnover in young individuals with Marfan syndrome: new insights from the AIMS trial. [PDF]
Eur Heart J Open, 2023 Background and aims: The fragmentation and loss of elastic fibre in the tunica media of the aorta is a pathological hallmark of Marfan syndrome (MFS) but the dynamics of elastin degradation and its relationship to aortic size and physiological growth ...
Iskandar Z +12 more
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Free Urinary Desmosine and Isodesmosine as COPD Biomarkers: The Relevance of Confounding Factors [PDF]
Chronic obstructive pulmonary diseases, 2016 Background: Desmosine (DES) and isodesmosine (IDES) have been widely discussed as potential biomarkers of COPD. However, their clinical utility and validity remains unproven.
Sara Ongay +6 more
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Characteristics of alpha-1 antitrypsin deficiency related lung disease exacerbations using a daily symptom diary and urinary biomarkers. [PDF]
PLoS ONEBackgroundPulmonary exacerbations in alpha-1 antitrypsin deficiency (AATD) related lung disease are a significant contributor to disease burden, as with usual COPD.
Paul Ellis +8 more
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ERJ Open Research, 2019 Monitoring the integrity of the lungs using biomarkers is a major goal as an indicator for patient prognosis, especially in diseases like cystic fibrosis (CF) where 85% of mortality is a result of lung disease [1].
Shuren Ma +5 more
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Impact of Spirometrically Confirmed Chronic Obstructive Pulmonary Disease on Arterial Stiffness and Surfactant Protein D After Percutaneous Coronary Intervention. The CATEPOC Study [PDF]
International Journal of COPD, 2022 Komal Malik,1 Susana Diaz-Coto,2 Maria de la Asunción Villaverde,1 Pablo Martinez-Camblor,3,4 Annie Navarro-Rolon,5,6 Francisco Pujalte,6 Alejandro De la Sierra,1 Pere Almagro1 1Internal Medicine Service, University Hospital Mútua de Terrassa, University
Malik K +7 more
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126 Urinary desmosine, a biomarker of elastin degradation is significantly elevated and associated with maximum aortic root size and aortic Z-scores in patients with bicuspid aortic valve [PDF]
Valve Disease/Pericardial Disease/Cardiomyopathy, 2019 Introduction Bicuspid aortic valve (BAV) affects up to 2% of the general population and is associated with a significant risk of aortic dilatation and aortic dissection. Therefore, patients are normally routinely followed up with serial echocardiography.
Zaid Iskandar +10 more
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Plasma desmosine as a biomarker in acute aortic syndrome [PDF]
European Heart Journal, 2021 Alison Fletcher +8 more
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Biosynthetic pathway of desmosines in elastin [PDF]
Biochemical Journal, 1973 1. Elastins purified by various methods from the ligamentum nuchae and the lungs of cattle of various ages were analysed for amino acid compositions and lysine-derived cross-links. 2. In fully mature elastins from adults the main cross-links were desmosine, isodesmosine and lysinonorleucine and the so-called aldol-condensation product. Trace amounts of
G. E. Francis +2 more
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Corrigendum: Effects of Vitamin D and K on Interleukin-6 in COVID-19 [PDF]
Frontiers in Nutrition, 2022 Margot P. J. Visser +7 more
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