Results 41 to 50 of about 2,402 (209)

Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing [PDF]

, 2017
Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding
A Heinz, AJ Viera, B Vrhovski, C Thorpe, C Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, D Bedell-Hogan, EL Batson, F Ramirez, H Birch, H Oxlund, H Tempfer, HL Birch, IM Braverman, J Fallon, JA Foster, JA Foster, JA Pierce, JE Wagenseil, JF Innes, K Kubo, KD Smith, L Nimeskern, L Robert, L Robert, M Akagawa, M Benjamin, M Luisetti, MJ Sherratt, P Berens, P Kannus, PPY Lui, R Alexander, R Ker, SA Fenwick, SE Greenwald, SG Dakin, T Watanabe, TB Csóka, TC Lee, TM Grant, TM Grant, Z Gunja-Smith, Z Liu   +48 more
core   +4 more sources

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +2 more sources

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]

, 2017
Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa, Barnette, Basalyga, Bonow, Brown-Augsburger, Brunskill, Brunskill, Chung, Fondard, Franco, Gallegos, Gapski, Ghosh, Gu, Helske, Hinton, Hinton, Holm, Ihn, Iverson, Jensen, Keane, Krenz, Liang, Lindeman, Marshall, Mercer, Mohler, Mozaffarian, Munjal, Nishimura, Nkomo, Perrotta, Poggio, Potter, Rajamannan, Rossebo, Sauls, Schmieder, Schoen, Starcher, Vesely, Wirrig, Wylie-Sears, Xiong, Xiong   +45 more
core   +2 more sources

Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease [PDF]

, 2016
Chronic obstructive pulmonary disease (COPD) is primarily a lung condition characterised by the presence of persistent airflow limitation resulting from inflammation, remodelling of small airways, and emphysema.
, Bolton, Charlotte E., Huang, Jeffrey T. J., MacNee, William, Miller, Bruce E., Palmer, Colin N. A., Rabinovich, Roberto A., Tal-Singer, Ruth, Thomson, Neil C.   +8 more
core   +3 more sources

Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice [PDF]

, 2006
Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor in aging and diseases.
Broekelmann, Thomas J, Chen, Qiuyun, Horiguchi, Masahito, Marmorstein, Alan D, Marmorstein, Lihua Y, McKay, Brian, McLaughlin, Precious J, Mecham, Robert, Nakamura, Tomoyuki, Stanton, J. Brett, Starcher, Barry C   +10 more
core   +3 more sources

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation. [PDF]

Adv Healthc Mater
Elastin and elastic fibers are essential components that provide elasticity and resilience to various tissues in the human body, including the skin. The main challenge arises after severe wounding, when elastic fibers need to be regenerated. This review provides a comprehensive summary of potential triggers for elastogenesis that may be further applied
Krymchenko R, Coşar Kutluoğlu G, van Hout N, Manikowski D, Doberenz C, van Kuppevelt TH, Daamen WF.   +6 more
europepmc   +2 more sources

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation [PDF]

, 2015
MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
Heumüller, Stefanie E, Holm, Anne T, Holmskov, Uffe, Moeller, Jesper B, Moestrup, Soren K, Pilecki, Bartosz, Schlosser, Anders, Sengle, Gerhard, Sorensen, Grith L, Wallis, Russell, Wohl, Alexander P, Zuk, Alexandra V   +11 more
core   +1 more source

Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea

Asian Journal of Andrology, 2020
This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control,
Tao Li, Fu-Dong Fu, Chang-Jing Wu, Feng Qin, Run Wang, Jiu-Hong Yuan   +5 more
doaj   +1 more source

Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?

European Journal of Organic Chemistry, Volume 2020, Issue 34, Page 5514-5522, September 14, 2020., 2020
Pd/C‐mediated dearomatic hydrogenation under ambient conditions such as balloon pressure and room temperature can be a powerful tool for constructing alicyclic skeletons. Density functional theory calculations have been performed to confirm the mechanistic aspects and the utility of the established methodology has been demonstrated by donepezil ...
Nao Tanaka, Toyonobu Usuki
wiley   +1 more source

Unique molecular networks: Formation and role of elastin cross‐links

IUBMB Life, Volume 72, Issue 5, Page 842-854, May 2020., 2020
Abstract Elastic fibers are essential assemblies of vertebrates and confer elasticity and resilience to various organs including blood vessels, lungs, skin, and ligaments. Mature fibers, which comprise a dense and insoluble elastin core and a microfibrillar mantle, are extremely resistant toward intrinsic and extrinsic influences and maintain elastic ...
Christian E. H. Schmelzer, Tobias Hedtke, Andrea Heinz   +2 more
wiley   +1 more source