Asian Journal of Andrology, 2020 This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control,
Tao Li +5 more
doaj +1 more source
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation [PDF]
, 2015 MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
Heumüller, Stefanie E +11 more
core +1 more source
Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?
European Journal of Organic Chemistry, Volume 2020, Issue 34, Page 5514-5522, September 14, 2020., 2020 Pd/C‐mediated dearomatic hydrogenation under ambient conditions such as balloon pressure and room temperature can be a powerful tool for constructing alicyclic skeletons. Density functional theory calculations have been performed to confirm the mechanistic aspects and the utility of the established methodology has been demonstrated by donepezil ...
Nao Tanaka, Toyonobu Usuki
wiley +1 more source
Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease [PDF]
, 2016 Chronic obstructive pulmonary disease (COPD) is primarily a lung condition characterised by the presence of persistent airflow limitation resulting from inflammation, remodelling of small airways, and emphysema.
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core +2 more sources
Unique molecular networks: Formation and role of elastin cross‐links
IUBMB Life, Volume 72, Issue 5, Page 842-854, May 2020., 2020 Abstract Elastic fibers are essential assemblies of vertebrates and confer elasticity and resilience to various organs including blood vessels, lungs, skin, and ligaments. Mature fibers, which comprise a dense and insoluble elastin core and a microfibrillar mantle, are extremely resistant toward intrinsic and extrinsic influences and maintain elastic ...
Christian E. H. Schmelzer +2 more
wiley +1 more source
Elastin haploinsufficiency induces alternative aging processes in the aorta [PDF]
, 2008 Elastin, the main component of elastic fibers, is synthesized only in early life and provides the blood vessels with their elastic properties. With aging, elastin is progressively degraded, leading to arterial enlargement, stiffening, and dysfunction ...
Boyle, Walter A +13 more
core +3 more sources
Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse
Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020 Pelvic organ prolapse is a frequent health problem in women, encountered worldwide, its physiopathology being still incompletely understood. The integrity of the pelvic‐supportive structures is a key element that prevents the prolapse of the pelvic organs.
Radu Dragos Marcu +9 more
wiley +1 more source
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources
Quantification of desmosine and isodesmosine using MALDI-ion trap tandem mass spectrometry [PDF]
Analytical and Bioanalytical Chemistry, 2018 Pratikkumar Rathod +9 more
openalex +2 more sources
Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency? [PDF]
, 2017 Differentiating between chronic obstructive pulmonary disease (COPD) patients with normal (PiMM) or deficient (PiZZ) genetic variants of alpha-1 antitrypsin (A1AT) is important not only for understanding the pathobiology of disease progression but also ...
Carleo, Alfonso +7 more
core +2 more sources