Results 71 to 80 of about 3,049 (232)

Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice [PDF]

, 2006
Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor in aging and diseases.
Broekelmann, Thomas J, Chen, Qiuyun, Horiguchi, Masahito, Marmorstein, Alan D, Marmorstein, Lihua Y, McKay, Brian, McLaughlin, Precious J, Mecham, Robert, Nakamura, Tomoyuki, Stanton, J. Brett, Starcher, Barry C   +10 more
core   +3 more sources

Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency

Respiratory Research, 2005
Background The burden of proteinases from inflammatory cells in the lung of subjects with type Pi ZZ of alpha-1-antitrypsin deficiency is higher than in those without the deficiency.
Nieuwenhuizen Willem, van Kuppevelt Toine H, Versteeg Elly M, Zanone Chiara, Annovazzi Laura, Veldhuisen Barbara, Stolk Jan, Iadarola Paolo, Luisetti Maurizio   +8 more
doaj   +1 more source

Assessment of some biochemical markers in electronic nicotine device smokers in Diyala province [PDF]

Pharmacia
Background: Vaping has gained significant popularity among young people in recent years as an alternative to conventional smoking. Despite being promoted as a safer substitute, the health consequences of vaping remain largely unknown. One area of concern
Omar D. Salman, Hany Akeel Al-hussaniy, Mohammed Abdlrahman Abdmahdi, Suha Khaleel Ibrahim   +3 more
doaj   +3 more sources

Sterilization of lung matrices by supercritical carbon dioxide [PDF]

, 2016
Lung engineering is a potential alternative to transplantation for patients with end-stage pulmonary failure. Two challenges critical to the successful development of an engineered lung developed from a decellularized scaffold include (i) the suppression
Balestrini, Jenna L, Blatt, Kelly M S, Broekelmann, Tom J, Gard, Ashley L, Huie, Janet, Liu, Angela, Mecham, Robert P, Niklason, Laura E, Schwan, Jonas, Wilcox, Elise C, Zhao, Liping   +10 more
core   +2 more sources

Lysyl oxidase‐like 2 (LOXL2)‐mediated cross‐linking of tropoelastin

The FASEB Journal, Volume 33, Issue 4, Page 5468-5481, April 2019., 2019
ABSTRACTLysyl oxidases (LOXs) play a central role in extracellular matrix remodeling during development and tumor growth and fibrosis through cross‐linking of collagens and elastin. We have limited knowledge of the structure and substrate specificity of these secreted enzymes.
Christian E. H. Schmelzer, Andrea Heinz, Helen Troilo, Michael P. Lockhart‐Cairns, Thomas A. Jowitt, Marion F. Marchand, Laurent Bidault, Marine Bignon, Tobias Hedtke, Alain Barret, James C. McConnell, Michael J. Sherratt, Stéphane Germain, David J. S. Hulmes, Clair Baldock, Laurent Muller   +15 more
wiley   +1 more source

The Possible Pathophysiological Outcomes and Mechanisms of Tourniquet‐Induced Ischemia‐Reperfusion Injury during Total Knee Arthroplasty

Oxidative Medicine and Cellular Longevity, Volume 2018, Issue 1, 2018., 2018
Ischemia and reperfusion (I/R) injury induced by tourniquet (TQ) application leads to the release of both oxygen free radicals and inflammatory cytokines. The skeletal muscle I/R may contribute to local skeletal muscle and remote organ damage affecting outcomes after total knee arthroplasty (TKA).
Prangmalee Leurcharusmee, Passakorn Sawaddiruk, Yodying Punjasawadwong, Nipon Chattipakorn, Siriporn C. Chattipakorn, Luciano Saso   +5 more
wiley   +1 more source

Soluble Proteins From Conventional and Organic Eggshell Membranes With Different Proteomic Profiles Show Similar In Vitro Biofunctions

Journal of Biomedical Materials Research Part A, Volume 113, Issue 1, January 2025.
ABSTRACT The eggshell membrane (ESM), resembling the extracellular matrix (ECM), acts as a protective barrier against bacterial invasion and offers various biofunctions due to its porous structure and protein‐rich composition, such as ovalbumin, ovotransferrin, collagen, soluble protein, and antimicrobial proteins.
Qianli Ma, Lya Piaia, Dagnija Loca, Kristaps Rubenis, Janis Locs, Bernd Thiede, Ólafur Eysteinn Sigurjónsson, Håvard Jostein Haugen   +7 more
wiley   +1 more source

Protein Based Nanostructures for Drug Delivery

Journal of Pharmaceutics, Volume 2018, Issue 1, 2018., 2018
The key role of protein based nanostructures has recently revolutionized the nanomedicine era. Protein nanoparticles have turned out to be the major grounds for the transformation of different properties of many conventional materials by virtue of their size and greater surface area which instigates them to be more reactive to some other molecules ...
Deepali Verma, Neha Gulati, Shreya Kaul, Siddhartha Mukherjee, Upendra Nagaich, Sumio Chono   +5 more
wiley   +1 more source

Neutrophil elastase in bronchiectasis

Respiratory Research, 2017
The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF.
Andrea Gramegna, Francesco Amati, Leonardo Terranova, Giovanni Sotgiu, Paolo Tarsia, Daniela Miglietta, Maria Adelaide Calderazzo, Stefano Aliberti, Francesco Blasi   +8 more
doaj   +1 more source

Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis [PDF]

, 2013
SummaryNeutrophil elastase (NE) activity is increased in bronchiectasis and may play a role in this condition. We wished to determine the effect of AZD9668, a selective oral inhibitor of NE.Efficacy and safety of AZD9668 60 mg twice daily over 4 weeks ...
De Soyza, Anthony, Entwistle, Neil, Forsman-Semb, Kristina, Gunawardena, Kulasiri, Perrett, John, Snell, Noel, Stockley, Robert   +6 more
core   +1 more source