Results 81 to 90 of about 3,049 (232)

Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

open access: yesJournal of Immunology Research, Volume 2017, Issue 1, 2017., 2017
Neutrophils are important effector cells of antimicrobial immunity in an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), there is excessive infiltration and activation of neutrophils, subsequent production of ...
Carina Kärrman Mårdh   +7 more
wiley   +1 more source

Topical Tretinoin Increases the Tropoelastin and Fibronectin Content of Photoaged Hairless Mouse Skin [PDF]

open access: yes, 1995
Topical tretinoin treatment of photoaged hairless mice has been shown in previous studies to stimulate formation of a subepidermal zone of new connective tissue characterized by enhanced collagen synthesis.
Kligman, Lorraine H., Schwartz, Elaine
core   +1 more source

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

open access: yesAdvanced Healthcare Materials, Volume 13, Issue 27, October 28, 2024.
Elastin and elastic fibers are essential components that provide elasticity and resilience to various tissues in the human body, including the skin. The main challenge arises after severe wounding, when elastic fibers need to be regenerated. This review provides a comprehensive summary of potential triggers for elastogenesis that may be further applied
Roman Krymchenko   +6 more
wiley   +1 more source

A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome

open access: yesDisease Markers, Volume 2016, Issue 1, 2016., 2016
Acute respiratory distress syndrome (ARDS) is an acute‐onset hypoxic condition with radiographic bilateral lung infiltration. It is characterized by an acute exudative phase combining diffuse alveolar damage and lung edema followed by a later fibroproliferative phase.
Raiko Blondonnet   +4 more
wiley   +1 more source

Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation [PDF]

open access: yes, 2012
BACKGROUND: Elastin is an essential component of selected connective tissues that provides a unique physiological elasticity. Elastin may be considered a signature protein of lungs where matrix metalloprotease (MMP) -9-and -12, may be considered the ...
Arkadiusz Nawrocki   +12 more
core   +1 more source

Label‐Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications

open access: yesAdvanced Materials, Volume 36, Issue 42, October 17, 2024.
This literature review examines the pivotal roles and applications of autofluorophores—endogenous fluorescent compounds intrinsic to all tissues. The utility of their assessment is explored in non‐invasive, label‐free clinical assessments for disease detection, surgical guidance, and continuous in vivo tissue characterization, highlighting their ...
Jared M. Campbell   +7 more
wiley   +1 more source

Perspectives on the Emerging Applications of Multifaceted Biomedical Polymeric Nanomaterials

open access: yesJournal of Nanomaterials, Volume 2015, Issue 1, 2015., 2015
Biodegradable and biocompatible polymeric nanomaterials, serving as biomedical devices have garnered significant attention as a promising solution to therapeutic management of many chronic diseases. Despite their potentials, majority of the synthetic nanomaterials used in biomedical applications lack crucial properties, for example, ligand binding ...
Ahmad Mohammed Gumel   +3 more
wiley   +1 more source

Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?

open access: yesRespiratory Research, 2017
Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more replaced by direct oral anticoagulants, vitamin
Ianthe Piscaer   +5 more
doaj   +1 more source

Factors determining persistent asymmetry and egg shape in birds: A hypothesis

open access: yesIbis, Volume 166, Issue 2, Page 551-559, April 2024.
The shape of birds' eggs has fascinated scientists for many years. It is now possible mathematically to describe shape accurately, allowing exploration of the physical and ecological factors driving the evolution of egg shape. However, there has been relatively little consideration of how egg shape is established in the oviduct or, given that even ...
Denis Charles Deeming
wiley   +1 more source

Dose-Dependent Prevention of Fibrosis in Aorta of Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats by Combined Delapril and Indapamide treatment. [PDF]

open access: yes, 2002
Combined treatment with the angiotensin-converting enzyme (ACE) inhibitor delapril and the diuretic indapamide prevented vascular damage in vital organs of salt-loaded stroke-prone spontaneously hypertensive rats (SHRsp).
B., Bacchelli   +5 more
core   +1 more source

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