Results 171 to 180 of about 4,329 (200)

Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases

Griffiths WJ, Asgari MA, Yutuc E, Abdel-Khalik J, Crick PJ, Morris AA, Jones SA, Ghosh A, Hart C, Schöls L, Matysik S, Laina I, Pickrell WO, Moat SJ, Wang Y.   +14 more
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Alzheimer's Disease: Brain Desmosterol Levels [PDF]

Journal of Alzheimer's Disease, 2013
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of the gene coding for the enzyme DHCR24, which metabolizes desmosterol to ...
Thomas, Wisniewski, Kia, Newman, Norman B, Javitt   +2 more
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Desmosterol in human milk

Lipids, 1983
AbstractMilk samples were collected from mothers at 2,6, 12 and 16 weeks postpartum. Desmosterol was found to be present in all the milk samples. Identification of desmosterol was based on retention times with two gas liquid chromatography (GLC) columns and verified by GC‐m ass spectrometry.
R M, Clark, M B, Fey, R G, Jensen, D W, Hill   +3 more
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Desmosterol in developing rat brain

Journal of the American Oil Chemists' Society, 1965
AbstractThe brain of the young rat contains appreciable amounts of desmosterol (24‐dehydrocholesterol). The peak desmosterol concentration is seen during the first week of life and only traces of this sterol are found at 21 days. The spinal cord also contains some desmosterol.
D, Kritchevsky, S A, Tepper, N W, DiTullio, W L, Holmes   +3 more
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HPLC analysis of desmosterol, 7‐dehydrocholesterol, and cholesterol

Lipids, 1989
AbstractA simple and sensitive method to analyzed mixtures of desmosterol, 7‐dehydrocholesterol and cholesterol is described. The method involves the oxidative conversion of the sterols with cholesterol oxidase, followed by high performance liquid chromatographic (HPLC) analysis.
E H, Goh, S M, Colles, K D, Otte
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Desmosterol als biogenetische vorstufe für convallamarogenin

Phytochemistry, 1974
Abstract Labelled 4- 14 C-desmosterol, but not cholesterol, is used by plants of Convallaria majalis L. for the biosynthesis of convallamarogenin. It can therefore be concluded that precursors of cholesterol biosynthesis can in some cases be converted directly into steroidal sapogenins, the pathway via cholesterol not always being obligatory.
Rudolf Tschesche, Hans W. Güttel, Gunter Josst   +2 more
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Desmosterol levels in human foetal brain—a reassessment

Journal of Neurochemistry, 1973
Cholesterol, an essential component of the central myelin sheath, is synthesized in large quantities during myelination in the central nervous system. However, in rat brain prior to and during the early stages of myelination desmosterol accumulates in significant amounts (Fumagalli and Paoletti, 1963; Kritchevsky and Holmes, 1962)
R G, Dennick, P D, Dean, D A, Abramovich
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ChemInform Abstract: NEW PREPARATION OF DESMOSTEROL (XI)

Chemischer Informationsdienst, 1974
AbstractAus dem Methylester (Ia) entsteht das Tosylat (Ib), das bei der Solvoly‐se in Gegenwart von Pyridin zu (II) führt.
S. K. DASGUPTA, D. R. CRUMP, M. GUT
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Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid

Steroids, 1977
A new synthesis of desmosterol was described using hyodeoxycholic acid (3alpha,6alpha-dihydroxy-5beta-cholanic acid) as a starting material. Epidesmosterol (3alpha-hydroxycholesta-5,24-diene) was also synthesized for the first time from the same starting material.
K, Ochi, I, Matsunaga, M, Shindo, C, Kaneko   +3 more
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