Results 201 to 210 of about 28,060 (246)

Albumin nanoparticles with predictable size by desolvation procedure

Journal of Microencapsulation, 2012
Nanoparticles prepared of human serum albumin (HSA) represent promising carriers for drug delivery. Desolvating procedure is a common method to obtain protein-based particles. However process parameters have a great influence on size, size distribution and particle yield of the resulting formulation.
Klaus Langer
exaly   +3 more sources

Desolvation process and surface characterisation of protein nanoparticles

International Journal of Pharmaceutics, 2000
The objective of the present study was to characterise and optimise the desolvation process of human serum albumin (HSA) for the preparation of nanoparticles and to characterise the resulting colloidal system. Following the desolvation of the protein, the resulting nanoparticles were stabilised by the addition of varying amounts of glutaraldehyde or by
Klaus Langer, C Coester, J Kreuter
exaly   +3 more sources

Charge transport in desolvated DNA

The Journal of Chemical Physics, 2013
The conductivity of DNA in molecular junctions is often probed experimentally under dry conditions, but it is unclear how much of the solvent remains attached to the DNA and how this impacts its structure, electronic states, and conductivity. Classical MD simulations show that DNA is unstable if the solvent is removed completely, while a micro-hydrated
Wolter, Mario, Elstner, Marcus, Kubar, Tomas   +2 more
openaire   +3 more sources

Polymorphism and desolvation of flupirtine maleate

European Journal of Pharmaceutics and Biopharmaceutics, 1998
Crystallizates of the analgesic agent flupirtine maleate (Katadolon; ASTA Medica, Dresden, Germany) obtained from isopropanol are examined by X-ray diffractometry, polarization microscopy and thermoanalysis. Depending on the crystallizing conditions, the modifications A and B as well as an isopropanol solvate are observed. The inversion temperature A-->
K F, Landgraf, A, Olbrich, S, Pauluhn, P, Emig, B, Kutscher, H, Stange   +5 more
openaire   +2 more sources

Desolvation Kinetics of Sulfameter Solvates

Journal of Pharmaceutical Sciences, 2008
Solvates are often encountered in pharmaceutical solids and knowledge of their physical stability is necessary for their effective formulation. This work investigates the solid-state stability of five structurally related solvates of sulfameter (5-methoxysulfadiazine) by studying the kinetics of their desolvation reaction with thermogravimetric ...
Ammar, Khawam, Douglas R, Flanagan
openaire   +2 more sources

Preparation of BSA Nanoparticles by Desolvation Technique Using Acetone as Desolvating Agent

International Journal of Pharmaceutical Sciences and Nanotechnology, 2012
In order to see the functionality and toxicity of nanoparticles in various food and drug applications, it is important to establish procedures to prepare nanoparticles of a controlled size. Desolvation is a thermodynamically driven self-assembly process for polymeric materials.
Krishna Sailaja A, Amareshwar P
openaire   +1 more source

Impact Desolvation of Polymers Embedded in Nanodroplets

The Journal of Physical Chemistry B, 2011
Using molecular dynamics simulation, we study the desolvation process of a polymer-loaded droplet after collision with a wall. The energy and time dependence of the process is analyzed for various droplet-polymer combinations. By changing droplet size, polymer size, solvent, and polymer species, separately, we can assess the influence of these factors ...
Si Neng, Sun, Herbert M, Urbassek
openaire   +2 more sources

Desolvations of Solvated Organic Crystals

Molecular Crystals and Liquid Crystals, 1979
Abstract The appearance of water of hydration is common in crystals of both organic and inorganic compounds. A review of Molecular Structures and Dimensions1 indicates that more than 1000 crystal structures of solvates have been determined and water is by far the most frequent solvating species.
C. T. Lin, S. R. Byrn
openaire   +1 more source

Synthesis of silk-based microcapsules by desolvation and hybridization

Chemical Communications, 2014
Single-component porous silk microcapsules were synthesized by the one-step desolvation method using PLGA spheres as sacrificial templates. Subsequently, AuNRs-T5 were utilized to synthesize silk-based hybrid capsules, which not only capped the pores of the shell but also enhanced Raman scattering.
Bo, Du, Jingjie, Wang, Zhimin, Zhou, Hongbo, Tang, Xuemin, Li, Yingjie, Liu, Qiqing, Zhang   +6 more
openaire   +2 more sources

Dynamics of Hydrogen Bond Desolvation in Protein Folding

Journal of Molecular Biology, 2002
As proteins fold, a progressive structuring, immobilization and eventual exclusion of water surrounding backbone hydrogen bonds takes place. This process turns hydrogen bonds into major determinants of the folding pathway and compensates for the penalty of desolvation of the backbone polar groups. Taken as an average over all hydrogen bonds in a native
Ariel, Fernández, Tobin R, Sosnick, Andrés, Colubri   +2 more
openaire   +2 more sources