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Unravelling venetoclax solvate behaviour: insights from crystal structures and computational surface analysis [PDF]
IUCrJThis study investigates venetoclax solvates and their nonsolvated forms through desolvation. Seven solvates were prepared and their structures solved from single-crystal X-ray diffraction data.
Eliška Zmeškalová +8 more
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X-Ray Structures, Intermolecular Interactions, and Structural Transformations of Dihydroquercetin Solvates and Polymorphs [PDF]
PharmaceuticsBackground/Objectives: Dihydroquercetin, known for its broad biological activities, is a key component in dietary supplements and functional foods. This study aims to identify its novel pure solid forms, advancing understanding of its physicochemical ...
Xin Meng +6 more
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Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation [PDF]
MoleculesAxitinib (AXTN) is an oral tyrosine kinase inhibitor for the treatment of early to advanced renal cell carcinoma. In this work, solvates of AXTN were prepared in five solvents and subjected to desolvation treatment.
Yinhu Pan +5 more
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Thermally tunable naphthalene diimide solvates enable selective sensing, reversible photochromism, and anti-counterfeiting applications [PDF]
Frontiers in ChemistryRecent studies have highlighted the potential of naphthalene diimide (NDI)-based molecules for their stimuli-responsive and optical properties. In this work, we report two naphthalene diimide (NDI)-based solvates, designated as NDI-1 and NDI-2, were ...
Loveleen Kaur +5 more
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Phase diagrams of pharmaceutical solvates from mechanochemistry [PDF]
Nature CommunicationsCrystalline solvates, including hydrates, hold untapped potential in pharmaceutical development, yet their exploitation remains minimal due to the difficult and laborious task of unequivocally establishing their physical stabilities.
Fragkoulis Theodosiou +5 more
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Formation of ibrutinib solvates: so similar, yet so different
IUCrJ, 2023 The transformation processes of non-solvated ibrutinib into a series of halogenated benzene solvates are explored in detail here. The transformation was studied in real time by X-ray powder diffraction in a glass capillary.
Jan Jirát +8 more
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Разработка и регистрация лекарственных средств, 2021 Introduction. Usage of aggressive conditions (solvents, high temperature, etc.) in a dosage form manufacturing can lead to a change in the properties of a pharmaceutical substance.
S. A. Zolotov +4 more
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Entrapped Transient Chloroform Solvates of Bilastine
Crystals, 2021 The knowledge about the solid forms landscape of Bilastine (BL) has been extended. The crystal structures of two anhydrous forms have been determined, and the relative thermodynamic stability among the three known anhydrous polymorphs has been ...
Cristina Puigjaner +4 more
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Pharmaceutics, 2021 Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives.
Debora Zanolla +8 more
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Formation of a solvate of manganese(III) acetylacetonate with chloroform
Конденсированные среды и межфазные границы, 2022 Metal acetylacetonates are coordination compounds consisting of the acetylacetonate anion (CH3COCHCOCH3, indicated as acac) and metal ions. Typically, both oxygen atoms of the anion bind with the metal and form a six-membered chelate ring.
Vladimir P. Zlomanov +2 more
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