Results 91 to 100 of about 11,274 (262)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

The role of social actors from the communication spaces. Some reflections for the analysis of tourism development

Santiago, 2015
The communication relationships among tourism stakeholders affect the characteristics of the destination, its attributes, or indicators of social impact; as an expression of the social structure that composes a tourism system.
MCs. Kirenis Milián-Borges
doaj  

Destination Attributes – Its Role on Constructing Image of Bandung as A MICE Destination in Indonesia

Kontigensi : Jurnal Ilmiah Manajemen, 2018
The MICE business continuously grow. Therefore, the MICE organizer provides an assessment of the city’s destination attributes. The purpose of this study is to disclose the forming factors of the destination. This study uses multiple regression analysis methods with a sample of 150 respondents. Two destination attributes as affordability and activities
openaire   +3 more sources

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Exploring senior-friendly tourism destination attributes—dimensions and prioritization

Humanities & Social Sciences Communications
This study adopts a mixed-method approach and examines senior-friendly destination attributes, aiming at understanding the dimensions of the destination attributes that the senior group perceives as important, as well as how these dimensions and ...
Pingping Hou, Lianping Ren, Yin Li, Jiewu Yao   +3 more
doaj   +1 more source

Attributes that influence resort attractiveness: a case study of selected Kimberley resorts. [PDF]

African Journal of Hospitality, Tourism and Leisure, 2017
Resorts have grown to dominate the accommodation sector of the world’s tourism industry and are known as the key building blocks of tourism due to the impact the latter has on local and international economies.
Rene Haarhoff, Kulsum B Gany
doaj  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The impact mechanism of social network information on tourism travel: an empirical analysis based on internet celebrity cities

Humanities & Social Sciences Communications
Social networks have profoundly influenced human thinking and behaviour patterns and have effectively promoted the development and evolution of the urban tourism economy.
Jian Chen, Xiaotong Wu, Yi Luo, Keliang Liu   +3 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source