Results 71 to 80 of about 11,274 (262)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Coastal Gastronomy and Destination Image: a Multidimensional Scaling Analysis of International Travellers about a Tropical Seafood Hub in India

open access: yesVallis Aurea
The study aims to analyse the perceptions of international tourists on coastal gastronomy and its influence in the destination image of Kerala, India. The study adopted a descriptive research design using a structured questionnaire having semantic diff ...
N Riswana   +2 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Electronic word-of-mouth intentions in personal and public networks: a domestic tourist perspective

open access: yesHumanities & Social Sciences Communications
This research investigated the determinants of electronic word-of-mouth (eWOM) sharing intentions in personal and public online networks among domestic tourists.
Manju Meenakshy   +3 more
doaj   +1 more source

Visitors’ Evaluation of Destination Attributes of Penglipuran Village

open access: yesE-Journal of Tourism, 2022
Destinations attributes are important aspects of a tourist destination that will determine visitors' satisfaction. They are also essential for the DMO to understand the strengths and weaknesses of the destination, thus providing the DMO with important information to further develop the destination.
openaire   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Exploring the Perceived Influence of Cinema on Destination Image, Destination Attributes and the Intention to Travel

open access: yesInternational Conference on Tourism Research
Cinema has long been acknowledged as a cultural mediator capable of shaping perceptions, imagery and attitudes associated with tourism destinations. However, empirical evidence regarding its influence on destination perceptions beyond single case studies remains limited.
Rosa Alexandra Meira da Cruz Lavaredas   +2 more
openaire   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

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