Results 91 to 100 of about 1,882,852 (292)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Identifying and Prioritizing the Factors Affecting the Choice of Medical Tourism Destination

مدیریت اطلاعات سلامت, 2018
Introduction: Despite the vast benefits of Iran in the field of medical tourism, the number of tourists entering the country for medical reasons is still negligible. The aim of this study was to identify and prioritize the factors affecting the choice of
Seyed Mohammadbagher Jafari, Gholamreza Jandaghi, Sahar Rafiee   +2 more
doaj   +1 more source

Truth and consequence: a look behind the Vatican's ban on contraception

, 2008
With these words slamming the door on Catholics’use of modern contraceptives, Pope Paul VI cleaved the Catholic church into irreconcilable factions 40 years ago. The majority, unable to reconcile the rigid encyclical with their need for an updated sexual
Catholics for Choice
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

THE IMPACT OF CLIMATE ON HOLIDAY DESTINATION CHOICE [PDF]

The holiday destination choice is analysed for tourists from 45 countries, representing all continents and all climates. Tourists are deterred by distance, political instability and poverty, and attracted to coasts. Tourists prefer countries with a sunny
Richard S.J. Tol, Jacqueline M. Hamilton, Andrea Bigano   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

TIKTOK, GEN Z, AND THE OVERTOURISM DILEMMA

Enlightening Tourism: A Pathmaking Journal
This study examines how TikTok content shapes Generation Z’s travel decision-making by exploring the roles of perceived destination image, Fear of Missing Out (FOMO), and perceived overtourism within the Stimulus–Organism–Response (S-O-R) framework.
Ariyaporn Sakulsom
doaj   +1 more source

Measuring the influence of the Camp de Tarragona high-speed rail station on first-time and repeat tourists visiting a coastal destination

Belgeo, 2016
This paper explores the effects of high-speed rail (HSR) services on the destination choice of first-time tourists and repeat tourists arriving in the Costa Daurada, a mature coastal destination in Catalonia, using HSR services.
Òscar Saladié, Salvador Anton Clavé, Aaron Gutiérrez   +2 more
doaj   +1 more source