Results 111 to 120 of about 1,882,852 (292)
The effect of income on the relationship between travel motives and destination choices
South African Journal of Economic and Management SciencesBackground: Studies investigating the relationship between travel motivations and destination choice are often unidimensional and hierarchical, presenting limited perspectives on traveller groups with diverse socioeconomic backgrounds.
Jarè Struwig, Elizabeth A. du Preez
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Incidencia de la renta en el comportamiento de los turistas en la selección de un destino turístico
Ciencia UNEMI, 2016 Ecuador is a rich country in culture and nature, which has a growing number of visitors and national tourists visiting the country. Tourist activity is necessary for all people as well as helping to prevent stress, it is an integral activity that ...
Ochoa-González, Carlos +2 more
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The Influence of Human Values on Holiday Destination Choice in Australia and Brazil [PDF]
BAR: Brazilian Administration Review, 2007 Allen and Ng (1999a) proposed a conceptual framework of how consumers’ choice of services may be influenced by the human values that they endorse. The aim of this study is to observe which implications cultural differences had on holiday destination ...
Amalia Raquel Pérez-Nebra +1 more
doaj
Competitiveness of Slovenia as a Tourist Destination [PDF]
In an increasingly saturated market the fundamental task for the destination management, is understanding how tourism destination competitiveness can be enhanced and sustained.
Doris Gomezelj Omerzel
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Unmanageable Tourism Destination Brands? [PDF]
Increasingly researchers and practitioners adopt branding to build and manage tourism destination images. However, we have yet to ask the question: Is it pos-sible to build and/or manage destination brands? This crucial question is ad-dressed by means of:
Bodil Stilling Blichfeldt
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