Results 121 to 130 of about 1,882,852 (292)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Dispersion or Concentration for the 1.5 Generation?: Destination Choices of the Children of Immigrants in the U.S. [PDF]

, 2006
This paper examines determinants of destination choice for foreign-born and 1.5 generation adult children of immigrants in the U.S. An immigrant concentration- weighted accessibility parameter is included to assess the spatial structure of destination ...
Jamie Goodwin-White (16051673), Goodwin-White, Jamie   +1 more
core   +1 more source

Dynamic Evolution of Multilevel Rail Transit Destination Choice Behavior Based on Disaggregate–Reinforcement Learning

Journal of Advanced Transportation
To address the distribution of origin–destination (OD) passenger flow in multilevel rail transit complex network, we propose a simulation method based on travel behavior and reinforcement learning for travelers’ multilevel rail transit network ...
Wei Gao, Enjian Yao, Yongsheng Zhang, Keyan Bai   +3 more
doaj   +1 more source

The Influence of Previous Visitation on Customer's Evaluation of a Tourism Destination [PDF]

The paper investigates the customer's perspective on a tourism destination brand through four proposed dimensions: awareness, image, quality and loyalty dimension.
Maja Konecnik, Mitja Ruzzier
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Exploring Determinants of International Students’ Satisfaction and Destination Choice: A Study of South Korea’s Higher Education Landscape

Trends in Higher Education
As South Korea positions itself as a competitive global education hub, understanding the determinants that attract and satisfy international students is critical.
Choong Mok Kwak, Kalu Ibe Ekpeghere, Duke Ohene Ofosu-Anim   +2 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Digital Trojan horse – urban tools in a non-urban environment. How to inform tourist travel decisions by means of a multi-service mobile app

Journal of Urban Mobility
This study examines the impact of a multi-service mobile app on tourist decision-making across three key stages: destination selection, long-distance travel, and local mobility at the destination.
Bartosz Bursa, Felix Mölk, Gottfried Tappeiner, Sebastian Vicoli, Alessa Heeß, Markus Mailer   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source