Results 31 to 40 of about 26,269 (261)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Influence of Origin Attributes on the Destination Choice of Discretionary Home-Based Walk Trips
ISPRS International Journal of Geo-InformationWalking has been recognized as an important mode of transportation in recent years, and recent research has improved travel demand models for walk trips.
Salman Aghidi Kheyrabadi +1 more
doaj +1 more source
Improving Destination Choice Modeling Using Location-Based Big Data
ISPRS International Journal of Geo-Information, 2017 Citizens are increasingly sharing their location and movements through “check-ins” on location based social networks (LBSNs). These services are collecting unprecedented amounts of big data that can be used to study how we travel and interact with our ...
Joseph Molloy, Rolf Moeckel
doaj +1 more source
A CATREG model of destination choice for a mature Island destination
Journal of Destination Marketing & Management, 2018 Abstract This paper explores the factors that most strongly influence the attraction of tourists by mature island destinations during the stagnation phase of the resort lifecycle. Many such destinations have attempted to develop ex nihilo strategies, typically in the form of product differentiation.
Almeida, António, Garrod, Brian
openaire +5 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Asian Journal of Shipping and LogisticsFreight transportation modeling represents the economic demand for moving goods across spatial networks. Traditional models often treat transportation mode and destination choice as separate processes.
Shahriar Afandizadeh +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Journal of Transport and Land Use, 2014 Transport planning relies extensively on forecasts of traveler behavior over horizons of 20 years and more. Implicit in such forecasts is the assumption that travelers’ tastes, as represented by the behavioral model parameters, are constant over time. In
James Fox +3 more
doaj +1 more source