Results 51 to 60 of about 26,269 (261)

ANALYSIS OF THE GEOGRAPHICAL FACTORS INFLUENCING CHOICE OF INFORMAL FISH TRADE ROUTE AND DESTINATION BY FISH TRADERS BETWEEN MALAWI AND NEIGHBORING COUNTRIES

open access: yesDiscover Global Society
Choice of trade route and destination by cross border traders is an important decision in today’s increasingly cross border trade of products including fish.
Jabulani Nyengere   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Consumption Values and Destination Evaluation in Destination Decision Making [PDF]

open access: yesJournal of Spatial and Organizational Dynamics, 2014
Consumption values have received little attention in the tourism literature, comparing to such determinants of the consumer behavior as motivations, pull and push factors, satisfaction, quality, or destination image, etc.
Vasyl Denys, Júlio Mendes
doaj  

Microeconometric models of tourists' destination choice [PDF]

open access: yesRegional Science and Urban Economics, 1997
Abstract The focus of this paper is on the microeconometric analysis of spatial choice in a cross section. Nested multinomial logit models are used to analyze the determinants of individual choice among destinations and vacation activities. Cramer and Ridder's likelihood ratio test for pooled alternatives in multinomial logit models is sequentially ...
Eymann, Angelika, Ronning, Gerd
openaire   +5 more sources

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

A NEW APPROACH TO THE ANALYSIS OF VISITOR PERCEPTIONS TOWARDS A TOURISM DESTINATION: THE ROLE OF FOOD AND WINE EXPERIENCES [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
The study aims to propose a new approach to analyse visitor perceptions and experiences in a tourism destination. The purpose is to discuss how the discrete choice models can contribute to the analysis of the tourism destination in the visitor experience
Roberta CAPITELLO   +2 more
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

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