Results 51 to 60 of about 442,006 (276)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Impact of Tourism Services Quality on Tourism Destination Loyalty, Considering the Mediating Role of the Tourism Destination Image and the Tourists Satisfaction [PDF]

Muṭāli̒āt-i Mudīriyyat-i Gardishgarī, 2017
The aim of this study is to investigate the effect of tourism services quality on destination loyalty according to the mediating role of a destination mental image and the satisfaction of tourists.
kambiz heidarzadeh, کبری نجفی, سیدعلی حسینی   +2 more
doaj   +1 more source

The influence of tourist experiencescape and unique perceptions on destination satisfaction and loyalty: A study of natural and cultural tourism in Indonesia

Journal of Enterprise and Development, 2023
Purpose — This study aims to analyze the role of the tourist experience and unique perceptions of a destination on destination satisfaction and loyalty in natural and cultural tourism models in Indonesia.
Fansuri Munawar, Rini Handayani
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developing a model for explaining tourism destination brand equity (Case study: Isfahan City) [PDF]

‫مدیریت بازرگانی, 2014
The purpose of this study is to develop a brand equity model for Isfahan as a tourism destination. The statistical population of this study consists of the inbound tourists who have traveled to Isfahan in November 2013.
Mohammad Ghafari, Bahram Ranjbarian, Saeed Fathi   +2 more
doaj   +1 more source

Positioning Malaysia as a Tourist Destination Based on Destination Loyalty

Asian Social Science, 2012
This study was conducted to ascertain the image of Malaysia as a tourist destination and examines the construct's influence on tourists' destination loyalty.Questionnaires were distributed to the departing foreign tourists at two of Malaysia's international airports.The collected data was analyzed using Structural Equation Modeling (SEM).The findings ...
Mahadzirah Mohamad, A. Asma', Nur Izzati Ab Ghani, Ahmad Rusdi Abdullah, Safiek Mokhlis   +4 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Destination love in Asia: Understanding the role of experiences and perceived value in building tourist loyalty

Asian Management and Business Review
This study proposes an integrated model to investigate how destination experience, destination love, and perceived value drive tourist loyalty, underpinned by attachment theory and expectancy-value theory.
Lilik Wahyudi, Endang Hariningsih
doaj   +1 more source