Results 51 to 60 of about 4,786 (292)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Examining destination personality: Its antecedents and outcomes [PDF]

, 2018
This study of Sardinia, Italy, an island destination in the Mediterranean Sea, examines the role of involvement on destination personality formation process.
Christina Geng-Qing Chi, Del Chiappa, Giacomo, Chi, Christina Geng-Qing, Giacomo Del Chiappa, Pan, Li, Li Pan   +5 more
core   +1 more source

THE IMPACT OF AGROTOURISM DESTINATION IMAGE ON TOURIST’S LOYALTY IN ZAGHOUAN, TUNISIA: MODERATING ROLE OF VISIT’S EXPERIENCE [PDF]

Geo Journal of Tourism and Geosites
This study tests the influence of destination image on loyalty. It also examines the moderation effect of visitors’ experiences in the link between the two main components of destination image and loyalty.
Abu Elnasr E. SOBAIH, Hassane GHARBI, Imed ZAIEM, Nadir ALIANE   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

How destination image and knowledge shape loyalty to halal tourism destinations: The role of social media [PDF]

The image and knowledge of a destination play a crucial role in influencing travel decisions. Within the context of Islamic traditions, many Muslim travelers prioritize halal certification when choosing a destination to visit.
Ishtiaque Arif, Ashikul Hoque
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Exploring Antecedents of Destination Loyalty: A Comprehensive Analysis of Island Destination Image, Brand Awareness and Satisfaction [PDF]

, 2023
This study examines the antecedents of destination loyalty and its relation to destination image (cultural image, environmental image, and socio-economic image), brand image and awareness and destination satisfaction in island destinations.
Wijaya, Atikah, Pramono, Suwito Eko, Ghazali, Ayu Rohaidah, Zamzuri, Norol Hamiza, Hanafiah, Mohd Hafiz   +4 more
core   +2 more sources

Destination love in Asia: Understanding the role of experiences and perceived value in building tourist loyalty

Asian Management and Business Review
This study proposes an integrated model to investigate how destination experience, destination love, and perceived value drive tourist loyalty, underpinned by attachment theory and expectancy-value theory.
Lilik Wahyudi, Endang Hariningsih
doaj   +1 more source