Results 61 to 70 of about 4,786 (292)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Rural and Urban Land Tourism and Destination Image: A Dual-Case Study Approach Examining Energy-Saving Behavior and Loyalty

Land, 2022
Although the significance of destination image is acknowledged, its effect on tourist reactions, especially energy-saving behavior, remains unknown. This research aimed to explore tourist energy-saving behavior (TESB) and loyalty (TL) in a rural land ...
Wei Zheng, Hongliang Qiu, Alastair M. Morrison, Wei Wei, Xihua Zhang   +4 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

A Study of the Relationship among Destination Image, Satisfaction and Loyalty ─ National Scenic Area as a Destination [PDF]

, 2012
[[abstract]]National scenic area is one the important destination types in tourism markets in Taiwan. The main functions of such kind of destination are to connect local tourism industry development by comprehensive planning and public investment.
Lin, Hao-jyue
core  

The Main Factors Influencing the Destination Choice, Satisfaction and the Loyalty of Ski Resorts Customers in the Context of Different Research Approaches

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2015
The paper summarizes scientific approaches to researches in the field of destination choice, satisfaction and the loyalty of ski resorts customers. Information about existing models and trends from scientific journals are analysed.
Monika Bédiová, Kateřina Ryglová
doaj   +1 more source

Destination authentic value advantage: an SDL perspective

Management şi Marketing, 2021
This study aims to build a destination marketing conceptual model to bridge the research gap concerning managing a destination service-scape quality for enhancing destination loyalty.
Ferdinand Augusty Tae
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Does Sustainable Certification Knowledge Influence Tourist Behavior? [PDF]

, 2011
In this study, the investigators use scores from the Tourist Ecological Orientation (TEO) Scale (Uriely, Reichel & Shani, 2007) of Costa Rica visitors to understand how their ecological orientation and interest in ecological practices influence ...
James, J. Joy, Laura Reddick, J. Joy James, Reddick, Laura, Stuart Davis, Davis, Stuart, Stephanie West, West, Stephanie   +7 more
core   +2 more sources

Triggers For Destination Brand Loyalty Of Millennial Visitors To Natural Tourism Destinations

Jurnal Manajemen
This research investigates triggers for destination brand loyalty of millennial visitors to natural tourism destinations. This research focuses on millennial visitors who have come to several natural tourist destinations in Southern Sumatra, with a ...
Heri Setiawan, Rini, Alditia Detmuliati
doaj   +1 more source