Results 151 to 160 of about 273,460 (309)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Unique attributes of official endorsers in destination marketing. [PDF]

Sci Rep
Zhao Y, Li Y, Liu B, Chang H, Guo Y.
europepmc   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Tailoring Sieving Pores and Electrochemical Interface Intercalation for Mechanically Resilient Recycled Micro‐Silicon Anodes

Advanced Science, EarlyView.
Here, an innovative strategy is proposed, using micron‐sized Si recovered from photovoltaic waste as raw material, combined with electrochemical lithium alloying, reacting with CO2 to obtain sieve‐like porous structure design to overcome mechanical dynamic limitations.
Yunan Wei, Ruilin Wu, Shixin Liu, Han Liang, Runwei Mo   +4 more
wiley   +1 more source

National policies and public marketing for cultural tourism destination [PDF]

Tourism and traveling industry represents, at international level, the most dynamic economic sector. At the same time, the most important job creator and a source of national economies recovering.
Grigorescu, Adriana
core   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

QUALITY FROM THE VIEWPOINT OF TOURISM DESTINATION [PDF]

Service quality initiatives are high priorities in many tourism destinations, with expenditure seen as long-term investment for future growth and profitability.
Liliana Elmazi
core  

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

Advanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang, Shitao Dou, Yifan Wu, Mingguang Wang, Taibin Wu   +4 more
wiley   +1 more source

Influencer Marketing in Rural Tourism: Enhancing Destination Image and Encouraging Homestay Choices. [PDF]

F1000Res
Chauhan R, Shaktan A, Shukla A, Khunsathitchai K, Yadav N, Savanurmath J.   +5 more
europepmc   +1 more source