Results 91 to 100 of about 448,416 (286)

What attracts tourists to a destination? Is it attractions? [PDF]

open access: yesAfrican Journal of Hospitality, Tourism and Leisure, 2018
The role of attractions in tourism cannot be overemphasized since it is common knowledge that it is the attractions that draw travellers to an area without which, arguably, they would be no tourism.
Cecilia Ngwira, Zandivuta Kankhuni
doaj  

NATION BRANDS AND TOURIST DESTINATIONS – AN EXPLORATORY ANALYSIS OF ROMANIA IN THE CONTEXT OF CENTRAL AND EASTERN EUROPE MARKETS [PDF]

open access: yes
Creation, development and employment of brands have recently become activities thattend to expand beyond the sphere of marketing communication of the organization and generatingsignificant effects over the results of marketing activities and overall ...
Calin Veghes, Virgil Balaure
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

MANAGEMENT IN RURAL AREAS

open access: yesEkonomski Vjesnik, 2015
Croatia has been seeking to achive pre-war results in tourism since its independence. Rural tourism in Croatia based on family farma faces a number of problems legal foundations, the involement of local communities, inadequate entepreneur support etc ...
Danimir Štros   +2 more
doaj  

Hardware Impairments Aware Transceiver for Full-Duplex Massive MIMO Relaying

open access: yes, 2015
This paper studies the massive MIMO full-duplex relaying (MM-FDR), where multiple source-destination pairs communicate simultaneously with the help of a common full-duplex relay equipped with very large antenna arrays.
Ma, Wenfeng   +4 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

TRAVEL AND TOURISM COMPETITIVENESS OF THE WORLD’S TOP TOURISM DESTINATIONS: AN EXPLORATORY ASSESSMENT [PDF]

open access: yes
In the recent years, competitiveness has become one of the common conceptsemployed to approach and describe the sustainable development of the travel and tourism industry.Competitiveness of the travel and tourism industry, like of the tourist ...
Calin Veghes   +2 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

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