Results 71 to 80 of about 448,416 (286)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

From virtual to real

Cadernos de Geografia
This paper intends to examine the potential interconnections between two distinct domains: tourism and video games. The primary objective is to ascertain whether there is a relationship between these two areas and to determine the extent to which video ...
Nuno Carvalho, Luís Silveira
doaj   +1 more source

Seasonal Variation in 25(OH)D at Aberdeen (57°N) and Bone Health Indicators- Could Holidays in the Sun and Cod Liver Oil Supplements Alleviate Deficiency? [PDF]

, 2013
Vitamin D has been linked with many health outcomes. The aim of this longitudinal study, was to assess predictors of seasonal variation of 25-hydroxy-vitamin D (25(OH)D) (including use of supplements and holidays in sunny destinations) at a northerly ...
Aucott, Lorna, Black, Alison J., Fraser, William D., Macdonald, Helen M., Mavroeidi, Alexandra, Reid, David M.   +5 more
core   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The role of religiosity in enhancing tourist loyalty through halal tourism and quality services [PDF]

Innovative Marketing
Halal tourist destinations meet the needs of Muslim travelers while also being accessible to non-Muslim visitors. This study investigates the relationship between non-Muslim visitors’ loyalty to halal products and services and the growth of halal tourism,
Martaleni Martaleni, Sugeng Mulyono, Elok Sri Utami   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Analysis of the Main Components in the Evaluation of Tourism Performance in Romania (2014-2022): Essential Dimensions and Strategic Directions for Sustainable Development [PDF]

Ovidius University Annals: Economic Sciences Series
Tourism contributes significantly to economic and social development, but in Romania it faces challenges related to the capitalization of resources and infrastructure development.
Roxana-Marcela Zaharia , Cristina Elena Georgescu   +1 more
doaj  

SWOT analysis for development strategy for Silamci natural tourism object facilities in Garut

ARTEKS : Jurnal Teknik Arsitektur
Natural tourism contributes significantly to GDP (gross domestic product) and is a major part of the Indonesian economy. In 2022, Indonesia ranked 32nd in the Travel and Tourism Development Index (TTDI), indicating a 3.6 percent rise in the GDP ...
Mentari Sucia, Riska Belasunda
doaj   +1 more source

Selecting an IMC Career: Influences, Choices and Destinations [PDF]

, 2006
Integrated marketing communication incorporates both customer and non-customer stakeholder groups. While the literature commonly refers to this distinction as marketing communication and corporate communication, respectively, and practitioners accept the
Larkin, Ingrid, Mehta, Amisha, Xavier, Robina   +2 more
core   +1 more source