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The actin-depolymerizing factor destrin has an actin-stabilizing domain
Biochemistry and Cell Biology, 2001Destrin is a 19 kDa actin-depolymerizing protein of the ADFcofilin family. Destrin was digested with trypsin to a structurally stable 9.2 kDa fragment that contains the actin-binding sequence. The purified 9.2 kDa fragment has an actin filament stabilizing activity, rather than an actin filament depolymerizing activity. The deleted region is probably
Kiyotaka Tokuraku +2 more
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Journal of Biological Chemistry, 1990 Cofilin is a widely distributed actin-modulating protein that has the ability to bind along the side of F-actin and to depolymerize F-actin in a pH-dependent manner. We found that phosphatidylinositol (PI), phosphatidylinositol 4-monophosphate (PIP), and phosphatidylinositol 4,5-bisphosphate (PIP2) inhibited both actions of cofilin in a dose-dependent ...
I Yahara
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SRF'ing the actin cytoskeleton with no destrin
Physiological Genomics, 2008all living cells, including bacteria, require an intricate actin cytoskeleton for normal homeostasis. Once thought to be a static scaffold functioning solely to maintain cell shape, the actin cytoskeleton is now known to be a dynamic menagerie of proteins controlling such processes as migration ...
Joseph Miano
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Pancreatology, 2012
The small actin-binding protein destrin is one of the key regulators involved in remodeling of the actin cytoskeleton, a process crucial for cytokinesis, cell migration and polarized cell growth as well as for cancer cell migration and invasion.A novel ex vivo nerve invasion model mirroring perineural cancer cell invasion as a key feature of pancreatic
Tiago De Oliveira +2 more
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The small actin-binding protein destrin is one of the key regulators involved in remodeling of the actin cytoskeleton, a process crucial for cytokinesis, cell migration and polarized cell growth as well as for cancer cell migration and invasion.A novel ex vivo nerve invasion model mirroring perineural cancer cell invasion as a key feature of pancreatic
Tiago De Oliveira +2 more
exaly +3 more sources
Destrin deletion enhances the bone loss in hindlimb suspended mice
European Journal of Applied Physiology, 2012Destrin, also known as actin depolymerizing factor (ADF), is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-actin in a stoichiometric manner. Remodeling of the actin cytoskeleton through actin dynamics (assembly and disassembly of filamentous actin) is known to be essential for numerous basic biological ...
Feng, Shuang +7 more
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Physiological Genomics, 2014 Increased angiogenesis, inflammation, and proliferation are hallmarks of diseased tissues, and in vivo models of these disease phenotypes can provide insight into disease pathology. Dstn corn1 mice, deficient for the actin depolymerizing factor destrin (DSTN), display an increase of serum response factor (SRF) that results in epithelial ...
Akihiro Ikeda +2 more
exaly +4 more sources
Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells [PDF]
International Journal of Cancer, 2007 Abstract Actin depolymerizing factor (ADF)/cofilin family proteins are key regulators of actin filament turnover and cytoskeleton reorganization. The role of cofilin‐1 in cell motility has been demonstrated in several cell types but remained poorly documented in the case of colon cancer.
Yann, Estornes +8 more
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Scandinavian Journal of Clinical and Laboratory Investigation, 2010
Our previous proteomic research has indicated that some cytoskeleton proteins show differential expression between thoracic aortic dissection and normal control groups, which suggests a possible mechanism involved in the pathogenesis of the vascular remodeling of this disease.
Zai-Ping Jing
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Our previous proteomic research has indicated that some cytoskeleton proteins show differential expression between thoracic aortic dissection and normal control groups, which suggests a possible mechanism involved in the pathogenesis of the vascular remodeling of this disease.
Zai-Ping Jing
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Advances in Enzyme Research, 2014 Destrin, also called actin-depolymerizing factor (ADF), exists in resting parotid tissue as phosphorylated (inactive) and dephosphorylated (active) forms, and β-adrenergic stimulation of this tissue induces dephosphorylation of destrin. It is suggested that destrin dephosphorylation is involved in cortical F-actin disruption observed in parallel with β-
Mamoru Matsubara
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Biochemistry, 1985
An Mr 19 000 protein (destrin) that has the ability to rapidly depolymerize F-actin in a stoichiometric manner was purified from porcine kidney by sequential chromatography on DNase I-agarose, hydroxyapatite, and Sephadex G-75. Its actin-depolymerizing activity is reversibly controlled by changes in KCl concentration but is insensitive to Ca2 ...
Hikoichi Sakai, Shohei Maekawa
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An Mr 19 000 protein (destrin) that has the ability to rapidly depolymerize F-actin in a stoichiometric manner was purified from porcine kidney by sequential chromatography on DNase I-agarose, hydroxyapatite, and Sephadex G-75. Its actin-depolymerizing activity is reversibly controlled by changes in KCl concentration but is insensitive to Ca2 ...
Hikoichi Sakai, Shohei Maekawa
exaly +3 more sources