Results 31 to 40 of about 567,162 (266)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Methodology and features of a computational experiment to assess the resource of responsible engineering facilities [PDF]
Известия Саратовского университета. Новая серия: Математика. Механика. ИнформатикаThe problem of obtaining estimates of the strength and resource characteristics of critical engineering infrastructure facilities under operational multiparametric nonstationary thermomechanical impacts is considered.
Volkov, Ivan A. +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The application of epoxy resin polymers by laser induction technologies
Science and Engineering of Composite MaterialsThe fabrication of robust and high-performance graphene-based electrodes on engineering plastics has garnered significant attention in recent years. In this study, we present a novel methodology to produce porous graphene structures derived from epoxy ...
Yu Chao +6 more
doaj +1 more source
THE FIELD OF RECENT TECTONIC STRESSES IN CENTRAL AND SOUTH-EASTERN ASIA
Геодинамика и тектонофизика, 2015 The publication presents results of the study aimed at reconstruction of recent crustal stresses for Central and South-Eastern Asia with application of the method of cataclastic analysis of displacements caused by ruptures, which was proposed by Yu.L ...
Yu. L. Rebetsky, R. S. Alekseev
doaj +1 more source
Theriologia Ukrainica, 2023 The article presents data on the extirpation of the wolf in southern Ukraine in the 18th to the 20th century, which was financially supported by landowners and the state.
Anatoliy Volokh
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
BuildingsIn near-fault regions, intense vertical seismic excitation combined with the widespread lack of tensile capacity in bridge bearings can readily induce vertical separation between piers and girders.
Chao Yang +8 more
doaj +1 more source
WHY WE CANNOT PREDICT STRONG EARTHQUAKES IN THE EARTH’S CRUST
Геодинамика и тектонофизика, 2015 In the past decade, earthquake disasters caused multiple fatalities and significant economic losses and challenged the modern civilization. The wellknown achievements and growing power of civilization are backstrapped when facing the Nature. The question
Iosif L. Gufeld +2 more
doaj +1 more source