Results 41 to 50 of about 567,162 (266)

The Destruction of ‘Mankind’

open access: yesZeitschrift für Ägyptische Sprache und Altertumskunde, 2022
Summary The phonological changes undergone by the word rmṯ, ‘person’, are shown to have clashed with its emblematic and almost logographic written form established at the end of the Old Kingdom. The orthography of the lexeme was highly resistant to alterations in its phonology, which resulted in two changes of its gender over time, from ...
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

The safe operations modes substantiation for water source wellbores of the Vadelypskoye deposit

open access: yesGeoresursy, 2018
The sand production problem for the water sources wellbores at the Vadelypskoye oilfield that is located in Hanty-Mansy region of Russia is considered. The serious issue during field operations is the open wellbore wall destruction even if low drawdown ...
A.V. Seryakov   +3 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

open access: yesFEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti   +5 more
wiley   +1 more source

Influence of Carbonization of Concrete Surfaces on their Adhesion with Freshly-Laid Concrete

open access: yesНаука и техника, 2021
During operation, concrete and reinforced concrete structures are exposed to the aggressive environment of carbon dioxide. During the reconstruction and overhaul of the berthing facilities in the coastal zone of the seas of the Far East, a weak bond ...
V. V. Molodin   +2 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

open access: yesFEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn   +2 more
wiley   +1 more source

Archéologie et création artistique

open access: yesLes Nouvelles de l’Archéologie, 2013
It is usually considered that artistic creation is oriented toward future, and archeology toward the past. Examination of the two practices shows that this opposition is misleading and that one and the other continued with the same strategies and ...
Luc Bachelot
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

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