Results 41 to 50 of about 2,073,712 (279)

Has Creative Destruction Become More Destructive? [PDF]

SSRN Electronic Journal, 2014
Abstract:Schumpeter’s concept of creative destruction as the engine of capitalist development is well-known. However, that the destructive part of creative destruction is a social and economic cost and therefore biases our estimate of the impact of the innovation on GDP is hardly acknowledged, with the notable exception of Witt (1996.
openaire   +5 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

THE FIELD OF RECENT TECTONIC STRESSES IN CENTRAL AND SOUTH-EASTERN ASIA

Геодинамика и тектонофизика, 2015
The publication presents results of the study aimed at reconstruction of recent crustal stresses for Central and South-Eastern Asia with application of the method of cataclastic analysis of displacements caused by ruptures, which was proposed by Yu.L ...
Yu. L. Rebetsky, R. S. Alekseev
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The application of epoxy resin polymers by laser induction technologies

Science and Engineering of Composite Materials
The fabrication of robust and high-performance graphene-based electrodes on engineering plastics has garnered significant attention in recent years. In this study, we present a novel methodology to produce porous graphene structures derived from epoxy ...
Yu Chao, Yang Weiwei, Meng Fanxing, Zhao Zhonghai, Cao Fubao, Xing Chengcheng, Du Jingxuan   +6 more
doaj   +1 more source

WHY WE CANNOT PREDICT STRONG EARTHQUAKES IN THE EARTH’S CRUST

Геодинамика и тектонофизика, 2015
In the past decade, earthquake disasters caused multiple fatalities and significant economic losses and challenged the modern civilization. The wellknown achievements and growing power of civilization are backstrapped when facing the Nature. The question
Iosif L. Gufeld, Margarita I. Matveeva, Oleg N. Novoselov   +2 more
doaj   +1 more source

Creative destruction and business cycles [PDF]

, 1995
In a dynamic general equilibrium setup, this paper aims at providing a general framework for the analysis of the role of vintages and creative destruetion on business fluctuations.
Boucekkine, Raouf, Germain, Marc, Licandro, Omar   +2 more
core   +1 more source

Tidal Destruction of The First Dark Microhalos [PDF]

, 2006
We point out that the usual self-similarity in cold dark matter models is broken by encounters with individual normal galactic stars on sub-pc scale. Tidal heating and stripping must have redefined the density and velocity structures of the population of
Angus, Garry W., Hooper, Dan, Silk, Joseph, Taylor, James E., Zhao, HongSheng   +4 more
core   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source