Results 51 to 60 of about 2,069,709 (280)

The safe operations modes substantiation for water source wellbores of the Vadelypskoye deposit

open access: yesGeoresursy, 2018
The sand production problem for the water sources wellbores at the Vadelypskoye oilfield that is located in Hanty-Mansy region of Russia is considered. The serious issue during field operations is the open wellbore wall destruction even if low drawdown ...
A.V. Seryakov   +3 more
doaj   +1 more source

Destruction of Refractory Carbon in Protoplanetary Disks [PDF]

open access: yes, 2017
The Earth and other rocky bodies in the inner solar system contain significantly less carbon than the primordial materials that seeded their formation. These carbon-poor objects include the parent bodies of primitive meteorites, suggesting that at least ...
Anderson, Dana E.   +5 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The Self-Destruction of Yugoslavia [PDF]

open access: yes, 2000
The self-destructiveness of the former Yugoslav federal system has not yet received its appropriate place in numerous accounts of the causes of Yugoslavia’s disintegration.
Guzina, Dejan
core   +1 more source

Galaxy destruction and diffuse light in clusters [PDF]

open access: yes, 2000
Deep images of the Centaurus and Coma clusters reveal two spectacular arcs of diffuse light that stretch for over 100 kpc, yet are just a few kpc wide. At a surface brightness of m_b \sim 27-28th arcsec^-2, the Centaurus arc is the most striking example ...
Bland-Hawthorn, J.   +4 more
core   +4 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Archéologie et création artistique

open access: yesLes Nouvelles de l’Archéologie, 2013
It is usually considered that artistic creation is oriented toward future, and archeology toward the past. Examination of the two practices shows that this opposition is misleading and that one and the other continued with the same strategies and ...
Luc Bachelot
doaj   +1 more source

Influence of Carbonization of Concrete Surfaces on their Adhesion with Freshly-Laid Concrete

open access: yesНаука и техника, 2021
During operation, concrete and reinforced concrete structures are exposed to the aggressive environment of carbon dioxide. During the reconstruction and overhaul of the berthing facilities in the coastal zone of the seas of the Far East, a weak bond ...
V. V. Molodin   +2 more
doaj   +1 more source

Creative destruction and business cycles [PDF]

open access: yes, 1995
In a dynamic general equilibrium setup, this paper aims at providing a general framework for the analysis of the role of vintages and creative destruetion on business fluctuations.
Boucekkine, Raouf   +2 more
core   +1 more source

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