Results 61 to 70 of about 2,073,712 (279)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Archéologie et création artistique
Les Nouvelles de l’Archéologie, 2013 It is usually considered that artistic creation is oriented toward future, and archeology toward the past. Examination of the two practices shows that this opposition is misleading and that one and the other continued with the same strategies and ...
Luc Bachelot
doaj +1 more source
Influence of Carbonization of Concrete Surfaces on their Adhesion with Freshly-Laid Concrete
Наука и техника, 2021 During operation, concrete and reinforced concrete structures are exposed to the aggressive environment of carbon dioxide. During the reconstruction and overhaul of the berthing facilities in the coastal zone of the seas of the Far East, a weak bond ...
V. V. Molodin +2 more
doaj +1 more source
Destruction of states in quantum mechanics
, 2001 A description of destruction of states on the grounds of quantum mechanics rather than quantum field theory is proposed. Several kinds of maps called supertraces are defined and used to describe the destruction procedure.
Ballentine L E +13 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Baryon Destruction by Asymmetric Dark Matter
, 2011 We investigate new and unusual signals that arise in theories where dark matter is asymmetric and carries a net antibaryon number, as may occur when the dark matter abundance is linked to the baryon abundance.
David E. Morrissey +4 more
core +1 more source
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Schemes for Privacy Data Destruction in a NAND Flash Memory
IEEE Access, 2019 We propose schemes for efficiently destroying privacy data in a NAND flash memory. Generally, even if privacy data is erased from NAND flash memories, there is a high probability that the data will remain in an invalid block. This is a management problem
Na-Young Ahn, Dong Hoon Lee
doaj +1 more source
Temporal characterization of rock dynamic destruction [PDF]
, 2019 Dynamic strength tests published in literature have been analysed by structuraltemporal damage criteria. Parameter τ - incubation time - describing material stability behaviour under high-rate influences have been estimated for Kimachi sandstone, Inada ...
Martemyanov, A. N., Petrov, Yu V.
core