Results 31 to 40 of about 611,923 (282)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Prevalence and macrolide resistance of Mycoplasma genitalium from patients seeking sexual health care in Southern Ghana

BMC Infectious Diseases
Background Mycoplasma genitalium (MG), a sexually transmitted infection (STI), has emerged as a common cause of non-gonococcal urethritis and cervicitis worldwide, with documented resistance to commonly used antibiotics including doxycycline and ...
Helena Dela, Eric Behene, Karen Ocansey, Jennifer N. Yanney, Kennedy Kwasi Addo, Hugo V. Miranda, Andrew G. Letizia, Anne T. Fox, Terrel Sanders, Naiki Attram   +9 more
doaj   +1 more source

Do Older Teachers Benefit More From Workday Break Recovery Than Younger Ones?

Scandinavian Journal of Work and Organizational Psychology, 2019
Age has not received much attention in research on work stress recovery. The present study addressed this research gap by studying whether age moderates the relationship between recovery experiences (detachment from work and relaxation) during workday ...
Ulla Kinnunen, Jessica de Bloom, Anniina Virtanen   +2 more
doaj   +1 more source

Perceived Community Cohesion and the Stress Process in Youth [PDF]

, 2011
Using survey data from two youth samples, one rural and one urban, we examine the role and significance of perceived community cohesion in the stress process. In particular, we assess the extent to which community attachment and detachment are related to
Cohn, Ellen S, Rebellon, Cesar J., Stracuzzi, Nena F., Tucker, Corinna Jenkins, Van Gundy, Karen T.   +4 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Reactivity of hydrated hydroxide anion cluster OH(H$_{2}$O)$_{n}^{-}$ with H and Rb: an ab initio study

, 2019
We present a theoretical investigation of the hydrated hydroxide anion clusters OH(H$_{2}$O)$_{n}^{-}$ and of the collisional complexes H-OH(H$_{2}$O)$_{n}^{-}$ and Rb-OH(H$_{2}$O)$_{n}^{-}$ (with n$=1-4$).
Kas, Milaim, Liévin, Jacques, Loreau, Jérôme, Vaeck, Nathalie   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The possibilities of increasing the reliability and durability of a cylindrical group by technological methods

Trudy Odesskogo Politehničeskogo Universiteta, 2018
The possibilities of increasing the reliability and durability of a cylindrical group by technological methods, in particular, the use of coatings from wear-resistant materials on the working surfaces of cylinders are considered.
A.Usov, M. Kunitsyn
doaj   +1 more source

Abrupt Bulla Formation by Visceral Pleural Detachment after Pulmonary Lobectomy: A Case Report

Journal of Chest Surgery, 2023
Pulmonary bullae usually grow slowly and have thin walls. However, we have observed 2 cases of abrupt bulla formation immediately after lobectomy and during surgery.
Byeong A Yoo, Seungmo Yoo, Jae Kwang Yun, Sehoon Choi   +3 more
doaj   +1 more source

The effect of surface roughness on the adhesion of elastic solids [PDF]

, 2001
We study the influence of surface roughness on the adhesion of elastic solids. Most real surfaces have roughness on many different length scales, and this fact is taken into account in our analysis.
B. N. J. Persson, Chiche A., E. Tosatti
core   +2 more sources