Results 41 to 50 of about 652,613 (355)

Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru

Revista da Sociedade Brasileira de Medicina Tropical, 2004
In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of ...
Alan J. Magill, Jorge Zegarra, Coralith Garcia, Wilmer Marquiño, Trenton K. Ruebush II   +4 more
doaj  

Determinants of effectiveness of scleral buckling as a primary care surgery in rhegmatogenous retinal detachment among underprivileged cases unable to afford vitrectomy

Journal of Clinical Ophthalmology and Research, 2015
Background: The purpose of this study was to determine the role of scleral buckling in the present era of pars plana vitrectomy and to evaluate the factors determining the outcome of buckling in terms of anatomical attachment of retina, visual recovery ...
Padma B Prabhu, Raju Kuzhupally Vallon
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Critical Approach to homo theoreticus in Victory by Joseph Conrad

Studia Warmińskie
In Victory (1915) Conrad portrays Axel Heyst, an ambiguous protagonist, who after his father’s death decides to follow his sceptical philosophy and practises radical detachment. However, an encounter with Lena and the assault of Mr.
Katarzyna Sokołowska
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The importance of militaries from developing countries in global infectious disease surveillance

Bulletin of the World Health Organization, 2007
Military forces from developing countries have become increasingly important as facilitators of their government's foreign policy, taking part in peacekeeping operations, military exercises and humanitarian relief missions.
Jean-Paul Chretien, David L Blazes, Rodney L Coldren, Michael D Lewis, Jariyanart Gaywee, Khunakorn Kana, Narongrid Sirisopana, Victor Vallejos, Carmen C Mundaca, Silvia Montano, Gregory J Martin, Joel C Gaydos   +11 more
doaj  

Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves. [PDF]

, 2019
Cell detachment is essential in culturing adherent cells. Trypsinization is the most popular detachment technique, even though it reduces viability due to the damage to the membrane and extracellular matrix.
Friend, James, Hirano, Makoto, Imashiro, Chikahiro, Kurashina, Yuta, Kuribara, Taiki, Ohnuma, Kiyoshi, Takemura, Kenjiro, Totani, Kiichiro   +7 more
core   +1 more source

Reactivity of hydrated hydroxide anion cluster OH(H$_{2}$O)$_{n}^{-}$ with H and Rb: an ab initio study

, 2019
We present a theoretical investigation of the hydrated hydroxide anion clusters OH(H$_{2}$O)$_{n}^{-}$ and of the collisional complexes H-OH(H$_{2}$O)$_{n}^{-}$ and Rb-OH(H$_{2}$O)$_{n}^{-}$ (with n$=1-4$).
Kas, Milaim, Liévin, Jacques, Loreau, Jérôme, Vaeck, Nathalie   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Diabetic Macular Edema With and Without Subfoveal Neuroretinal Detachment: Two Different Morphologic and Functional Entities [PDF]

, 2017
To assess specific morphologic and functional characteristics in eyes with diabetic macular edema (DME) with subfoveal neuroretinal detachment (SND+) vs DME without SND (SND-)
Berton, Marianna, Bini, Silvia, Convento, Enrica, Midena, Edoardo, Torresin, Tommaso, Vujosevic, Stela   +5 more
core   +1 more source