Results 41 to 50 of about 315,219 (254)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development of a Fully Automated Blood Alcohol Analyzer and Its Application in Forensic Science

Fayixue Zazhi
Blood alcohol concentration detection has long relied on manual operations in the field of forensic identification, resulting in cumbersome workflows, low throughput, and substantial human error.
TANG Lei, XIE Weihong, ZHUO Chengfei, XU Chen, YAO Huanhuan, LI Xiaofei, ZHANG Jianwei, LI Yang, YING Jianbo   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The importance of militaries from developing countries in global infectious disease surveillance

Bulletin of the World Health Organization, 2007
Military forces from developing countries have become increasingly important as facilitators of their government's foreign policy, taking part in peacekeeping operations, military exercises and humanitarian relief missions.
Jean-Paul Chretien, David L Blazes, Rodney L Coldren, Michael D Lewis, Jariyanart Gaywee, Khunakorn Kana, Narongrid Sirisopana, Victor Vallejos, Carmen C Mundaca, Silvia Montano, Gregory J Martin, Joel C Gaydos   +11 more
doaj  

Automated identification of the injury mechanism of ribs based on deep learning model

Discover Artificial Intelligence
Objective This study explores the application of deep learning in the classification of rib fracture injury mechanisms based on medical images. It aims to address the challenges of identifying rib fracture injury mechanisms and the complexity of network ...
Danxue Zhao, Shuo Yang, Jun Su, Xinyi Han, Jizhao Han, Peng Zhao   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Recovery during Lunch Breaks: Testing Long-Term Relations with Energy Levels at Work

Scandinavian Journal of Work and Organizational Psychology, 2016
This study had two aims. First, we examined whether lunch break settings, activities, and recovery experiences were associated with lunchtime recovery cross-sectionally. Second, we investigated whether lunchtime recovery was related to energy levels (i.e.
Marjaana Sianoja, Ulla Kinnunen, Jessica de Bloom, Kalevi Korpela, Sabine Geurts   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mine-Blast Injury with Partial Avulsion of the Upper Extremity. Surgical Treatment at a Military Field Hospital in the Special Military Operation Zone

Инновационная медицина Кубани
A 36-year-old serviceman sustained a mine-blast injury with partial avulsion of the left upper extremity at the mid-forearm level while performing a combat mission in the Special Military Operation zone.
A. N. Kazantsev, I. K. Gaptrakipov, N. A. Pavlenko, A. A. Popov, N. G. Shengelia, D. Yu. Neskoromny   +5 more
doaj   +1 more source

Do Older Teachers Benefit More From Workday Break Recovery Than Younger Ones?

Scandinavian Journal of Work and Organizational Psychology, 2019
Age has not received much attention in research on work stress recovery. The present study addressed this research gap by studying whether age moderates the relationship between recovery experiences (detachment from work and relaxation) during workday ...
Ulla Kinnunen, Jessica de Bloom, Anniina Virtanen   +2 more
doaj   +1 more source