Results 31 to 40 of about 219,126 (267)

Abrupt Bulla Formation by Visceral Pleural Detachment after Pulmonary Lobectomy: A Case Report

Journal of Chest Surgery, 2023
Pulmonary bullae usually grow slowly and have thin walls. However, we have observed 2 cases of abrupt bulla formation immediately after lobectomy and during surgery.
Byeong A Yoo, Seungmo Yoo, Jae Kwang Yun, Sehoon Choi   +3 more
doaj   +1 more source

Meister Eckhart: Principles of his Mysticism and Metaphysics

Sententiae, 2021
Meister Eckhart’s mysticism of the ground of the soul is considered as the inner connection between God and man. The ground of the soul and the ground of God are in reality one ground.
Roland Pietsch
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Determinants of effectiveness of scleral buckling as a primary care surgery in rhegmatogenous retinal detachment among underprivileged cases unable to afford vitrectomy

Journal of Clinical Ophthalmology and Research, 2015
Background: The purpose of this study was to determine the role of scleral buckling in the present era of pars plana vitrectomy and to evaluate the factors determining the outcome of buckling in terms of anatomical attachment of retina, visual recovery ...
Padma B Prabhu, Raju Kuzhupally Vallon
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The importance of militaries from developing countries in global infectious disease surveillance

Bulletin of the World Health Organization, 2007
Military forces from developing countries have become increasingly important as facilitators of their government's foreign policy, taking part in peacekeeping operations, military exercises and humanitarian relief missions.
Jean-Paul Chretien, David L Blazes, Rodney L Coldren, Michael D Lewis, Jariyanart Gaywee, Khunakorn Kana, Narongrid Sirisopana, Victor Vallejos, Carmen C Mundaca, Silvia Montano, Gregory J Martin, Joel C Gaydos   +11 more
doaj  

Automated identification of the injury mechanism of ribs based on deep learning model

Discover Artificial Intelligence
Objective This study explores the application of deep learning in the classification of rib fracture injury mechanisms based on medical images. It aims to address the challenges of identifying rib fracture injury mechanisms and the complexity of network ...
Danxue Zhao, Shuo Yang, Jun Su, Xinyi Han, Jizhao Han, Peng Zhao   +5 more
doaj   +1 more source

A Critical Approach to homo theoreticus in Victory by Joseph Conrad

Studia Warmińskie
In Victory (1915) Conrad portrays Axel Heyst, an ambiguous protagonist, who after his father’s death decides to follow his sceptical philosophy and practises radical detachment. However, an encounter with Lena and the assault of Mr.
Katarzyna Sokołowska
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source