Results 41 to 50 of about 611,923 (282)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Determinants of effectiveness of scleral buckling as a primary care surgery in rhegmatogenous retinal detachment among underprivileged cases unable to afford vitrectomy

Journal of Clinical Ophthalmology and Research, 2015
Background: The purpose of this study was to determine the role of scleral buckling in the present era of pars plana vitrectomy and to evaluate the factors determining the outcome of buckling in terms of anatomical attachment of retina, visual recovery ...
Padma B Prabhu, Raju Kuzhupally Vallon
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru

Revista da Sociedade Brasileira de Medicina Tropical, 2004
In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of ...
Alan J. Magill, Jorge Zegarra, Coralith Garcia, Wilmer Marquiño, Trenton K. Ruebush II   +4 more
doaj  

A Critical Approach to homo theoreticus in Victory by Joseph Conrad

Studia Warmińskie
In Victory (1915) Conrad portrays Axel Heyst, an ambiguous protagonist, who after his father’s death decides to follow his sceptical philosophy and practises radical detachment. However, an encounter with Lena and the assault of Mr.
Katarzyna Sokołowska
doaj   +1 more source

Reconsidering feminisms and the work of Norbert Elias for understanding gender, sport and sport-related activities [PDF]

, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2008 North West Counties Physical Education Association and SAGE Publications.This paper reconsiders the relationships between feminist ...
Mansfield, L., Mansfield, L.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Application of IMA and H-FABP in Forensic Diagnosis of Sudden Cardiac Death [PDF]

Fayixue Zazhi, 2017
 Acute myocardial ischemia is the most common cause of sudden cardiac death. The diagnosis of early myocardial ischemia is a hot point in forensic medicine, which is also an early and important part for a prevention against myocardial infarction ...
ZHU ZE-LEI, WANG PENG, YOU JIA-BIN, ET AL.
doaj   +1 more source

Adiabatic Theory of Electron Detachment from Negative Ions in Two-Color Laser Field [PDF]

, 1998
Negative ion detachment in bichromatic laser field is considered within the adiabatic theory. The latter represents a recent modification of the famous Keldysh model for multiphoton ionization which makes it quantitatively reliable.
A. Lohr, A. M. Perelomov, A. M. Perelomov, A. Szöke, B. Walker, B. Yang, C. Laughlin, Ce Chen, Ce Chen, D. A. Telnov, D. A. Telnov, D. B. Milosević, D. F. Zaretskii, D. W. Schumacher, D. Z. Anderson, E. Cormier, F. H. M. Faisal, G. F. Gribakin, G. F. Gribakin, G. F. Gribakin, G. G. Paulus, G. G. Paulus, G. G. Paulus, G. G. Paulus, G. G. Paulus, G. Yao, H. G. Muller, H. R. Reiss, I. Sánchez, J. Wang, J. Z. Kamińsky, J. Z. Kamińsky, K. J. Schafer, K. J. Schafer, L. A. A. Nikolopoulos, L. V. Keldysh, M. Dörr, M. Fifirig, M. Lewenstein, M. Protopapas, M. Yu. Kuchiev, M. Yu. Kuchiev, M. Yu. Kuchiev, M. Yu. Kuchiev, M. Yu. Kuchiev, N. B. Baranova, N. B. Baranova, N. B. Baranova, N. B. Baranova, R. M. Potvliege, R. M. Potvliege, R. M. Potvliege, S. Dionissopoulou, S. Wolfram, V. A. Pazdzersky, V. A. Pazdzersky, V. A. Pazdzersky, V. A. Pazdzersky, V. N. Ostrovsky, V. Véniard, W. Becker, W. Becker, X. Mu, X. Mu, Y.-Y. Yin   +64 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source