Results 51 to 60 of about 350,744 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Determinación de IgG y anticuerpos totales contra el Virus Dengue, en muestras obtenidas en papel filtro

Revista Peruana de Medicina Experimental y Salud Pública, 1997
Se propone como alternativa para la determinación de anticuerpos contra el virus del dengue, el uso de muestras de sangre total obtenidos en papel filtro, por ser un método sencillo y no requerir de muchos cuidados en el envío al laboratorio.
María García, César Cabezas, Johny Callahan, Benedicta Yana, Victoria Gutiérrez, Ana Ortiz, Elizabeth Anaya   +6 more
doaj  

Determination of the capabilities of a detachment for neutralizing chemical attack effects in the brigade defense zone [PDF]

Vojnotehnički Glasnik, 2012
This paper presents one possible way of deploying detachments for neutralizing the effects of chemical attacks in a brigade defense zone. The detachment composition is provisional and depends on the assessment of whether the enemy in the incoming combat ...
Dejan R. Inđić
doaj   +1 more source

The Relationship between Job Demands and Employees’ Counterproductive Work Behaviors: The Mediating Effect of Psychological Detachment and Job Anxiety

Frontiers in Psychology, 2017
This study aims to explore the relation between job demands and counterproductive work behaviors (CWBs). A cross-sectional sample of 439 coal miners completed a self-report questionnaire that assessed their job demands, psychological detachment, job ...
Yang Chen, Shuang Li, Qing Xia, Chao He
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Characterization of the materials of the ceiling that covers the Mayor Sacristhi of Seville's Cathedral

Materiales de Construccion, 2004
In this article we expose the technics used to characterize the materials of the ceiling that covers the Mayor sacristy of Seville's Cathedral and the causes of the loosening of mortar and stone fragments, we also expose some ways to overcome this fact.
J. Barrios, A. Barrios, C. Rodríguez
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Facilitated core-edge integration through divertor nitrogen seeding in the HL-2A tokamak

Nuclear Fusion
A divertor detachment with sustainable high-performance plasmas has been achieved through divertor nitrogen seeding in the HL-2A tokamak. The closed divertor structure facilitates achieving high divertor neutral pressure due to its efficient particle ...
N. Wu, J. Cheng, K.Y. Yi, R. Wang, M.K. Han, Z.H. Huang, W.C. Wang, Y. He, L.W. Yan, H.L. Du, J.M. Gao, H.C. Ma, X.X. He, Z.C. Yang, J. Wen, K. Zhang, T. Wu, W.P. Guo, X. Yu, L. Liu, Y.G. Li, L. Nie, Z.B. Shi, D.Z. Wang, W.L. Zhong   +24 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source