Results 111 to 120 of about 9,691,705 (303)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Interpretable and integrative analysis of single-cell multiomics with scMKL
Communications BiologyThe rapid advancement of single-cell technologies has led to the development of various analysis methods, each with trade-offs between predictive power and interpretability particularly for multimodal data integration.
Samuel D. Kupp +5 more
doaj +1 more source
, 1969 Compact automated laboratory unit has 60 independently treatable culture chamber assemblies for metabolic studies of cultured microorganisms on the surface of Mars or other ...
Martin, W. H.
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
BMC Infectious DiseasesBackground Acute respiratory tract infections are very common and can be caused by many pathogens. The aim of this study was to understand the characteristics of multi-pathogen infections of respiratory tract infections during the seasonal changes in ...
Jia Huang +7 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Journal of High Energy PhysicsHeavy flavour production in proton-proton (pp) collisions provides insights into the fundamental properties of Quantum Chromodynamics (QCD). Beauty hadron production measurements are widely performed through indirect approaches based on their inclusive ...
Xiaozhi Bai +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Detection of Citrus psorosis virus in field trees by direct tissue blot immunoasay in comparison with ELISA, symptomatology, biological indexing and cross-protection tests. [PDF]
, 2002 ALIOTO, DANIELA +4 more
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