Results 91 to 100 of about 114,821 (305)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Detection, attribution of long-term change, and event attribution

, 2016
This presentation covers the detection and attribution of long-term changes in climate and event attribution. Specific examples include Arctic sea ice extent, the 2013 flooding in Calgary and the summer of 2013 in China ...
Zwiers, Francis W.
core  

Detection of changes in temperature extremes during the second half of the 20th century [PDF]

, 2005
Since 1950, the warmest and coldest days and nights of the year have become warmer. Comparing these observations with climate model simulations in an optimal detection analysis shows a significant human influence on patterns of change in extremely warm ...
Brown, S., Christidis, N., Hegerl, G. C., Stott, P. A., Caesar, J.   +4 more
core   +1 more source

Combination of Internal Variability and Forced Response Reconciles Observed 2023–2024 Warming

Geophysical Research Letters
The record‐breaking global mean surface temperature (GMST) in 2023 and 2024 came as a surprise to the scientific community, raising the question whether it provides evidence for a recent abrupt increase in the forced global warming rate. Here, we provide
G. Gyuleva, R. Knutti, S. Sippel
doaj   +1 more source

The upper end of climate model temperature projections is inconsistent with past warming

Environmental Research Letters, 2013
Climate models predict a large range of possible future temperatures for a particular scenario of future emissions of greenhouse gases and other anthropogenic forcings of climate.
Peter Stott, Peter Good, Gareth Jones, Nathan Gillett, Ed Hawkins   +4 more
doaj   +1 more source

Attribute Learning for Network Intrusion Detection [PDF]

, 2016
Network intrusion detection is one of the most visible uses for Big Data analytics. One of the main problems in this application is the constant rise of new attacks. This scenario, characterized by the fact that not enough labeled examples are available for the new classes of attacks is hardly addressed by traditional machine learning approaches.
Jorge Luis Rivero Pérez, Bernardete Ribeiro   +1 more
openaire   +4 more sources

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source