Results 71 to 80 of about 114,821 (305)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Detection of human influence on a new, validated 1500-Year temperature reconstruction [PDF]

, 2007
Climate records over the last millennium place the twentieth-century warming in a longer historical context. Reconstructions of millennial temperatures show a wide range of variability, raising questions about the reliability of currently available ...
Allen, M., Hegerl, Gabriele C., Allen, Myles, Pollack, Henry N., Hegerl, G. C., Crowley, T. J., Pollack, H. N., Crowley, Thomas J., Hyde, William T., Smerdon, Jason E., Zorita, Eduardo, Smerdon, J., Zorita, E., Hyde, W. T., William T. Hyde, Eduardo Zorita, Gabriele C. Hegerl, Jason Smerdon, Thomas J. Crowley, Henry N. Pollack, Myles Allen   +20 more
core   +1 more source

Early and widespread emergence of regional warming is robust to observational and model uncertainty

Environmental Research Letters
The ability to distinguish observed climate change from naturally arising climate variability is one of the most fundamental findings in climate science.
Jonah Shaw, Nathan Lenssen
doaj   +1 more source

Contextual Attribution Maps-Guided Transferable Adversarial Attack for 3D Object Detection

Remote Sensing
The study of LiDAR-based 3D object detection and its robustness under adversarial attacks has achieved great progress. However, existing adversarial attack methods mainly focus on the targeted object, which destroys the integrity of the object and makes ...
Mumuxin Cai, Xupeng Wang, Ferdous Sohel, Hang Lei   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Do responses to different anthropogenic forcings add linearly in climate models?

Environmental Research Letters, 2015
Many detection and attribution and pattern scaling studies assume that the global climate response to multiple forcings is additive: that the response over the historical period is statistically indistinguishable from the sum of the responses to ...
Kate Marvel, Gavin A Schmidt, Drew Shindell, Céline Bonfils, Allegra N LeGrande, Larissa Nazarenko, Kostas Tsigaridis   +6 more
doaj   +1 more source

Human influence on frequency of temperature extremes

Environmental Research Letters, 2020
We investigate the influence of external forcings on the frequency of temperature extremes over land at the global and continental scales by comparing HadEX3 observations and simulations from the Coupled Model Intercomparison Programme Phase 6 (CMIP6 ...
Ting Hu, Ying Sun, Xuebin Zhang, Seung-Ki Min, Yeon-Hee Kim   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Anthropogenic climate change affects meteorological drought risk in Europe

Environmental Research Letters, 2016
Drought constitutes a significant natural hazard in Europe, impacting societies and ecosystems across the continent. Climate model simulations with increasing greenhouse gas concentrations project increased drought risk in southern Europe, and on the ...
L Gudmundsson, S I Seneviratne
doaj   +1 more source