Results 81 to 90 of about 114,821 (305)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The HadGEM3‐GC3.1 Contribution to the CMIP6 Detection and Attribution Model Intercomparison Project

Journal of Advances in Modeling Earth Systems
The UK contribution to the Detection and Attribution Model Intercomparison Project (DAMIP), part of the sixth phase of the Climate Model Intercomparison Project (CMIP6), is described.
Gareth S. Jones, Martin B. Andrews, Timothy Andrews, Ed Blockley, Andrew Ciavarella, Nikos Christidis, Daniel F. Cotterill, Fraser C. Lott, Jeff Ridley, Peter A. Stott   +9 more
doaj   +1 more source

An Autonomous AI-Driven Framework for Adaptive Cyber Deception with Real-Time Threat Detection and Behaviour-Based Attribution

Computers
Contemporary cyber threats increasingly employ multi-stage and behaviourally adaptive strategies that challenge static intrusion detection and non-adaptive deception mechanisms.
Muhammad Shahzad, Muhsin Hassanu Saleh, Raja Ujjan   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Watermark-based Detection and Attribution of AI-Generated Content [PDF]

Several companies--such as Google, Microsoft, and OpenAI--have deployed techniques to watermark AI-generated content to enable proactive detection. However, existing literature mainly focuses on user-agnostic detection.
Hu, Yuepeng, Jiang, Zhengyuan, Guo, Moyang, Gong, Neil Zhenqiang   +3 more
core   +1 more source

Chapter 10 - Detection and attribution of climate change: From global to regional [PDF]

, 2013
This chapter assesses the causes of observed changes assessed in Chapters 2 to 5 and uses understanding of physical processes, climate models and statistical approaches.
Overland, J., Hansingo, K., Gutzler, D., Jain, S., Zhang, X., Allen, M.R., Sebbari, R., Hegerl, G., Hu, Y., Perlwitz, J., Mokhov, I.I., AchutaRao, K.M., Stott, P.A., Bindoff, N.L., Gillett, N.   +14 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Improving Analogues-Based Detection & Attribution Approaches for Hurricanes

This paper presents a proof of concept for a new analogue- based framework for the detection and attribution of hurricane-related hazards. This framework addresses two important limitations of existing analogue-based methodologies: the lack of observed ...
Faranda, Davide, Lee, Chia-Ying, Vaittinada Ayar, Pradeebane, Bourdin, Stella, Camargo, Suzana, J, Lin, Jonathan, Vrac, Mathieu   +6 more
core   +1 more source