Results 131 to 140 of about 3,842,363 (279)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Improved YOLOv7 algorithm combined with computer vision for detecting dense small objects
Discover ComputingDense small object detection in complex scenes has always been a major challenge in the field of computer vision. A novel fusion detection framework is proposed to address the shortcomings of existing methods in terms of detection accuracy, computational
Yun Du
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Area-capability Concept: Promoting the Use of Local Resources [PDF]
, 2015 application ...
イシカワ, サトシ +9 more
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Project Gatekeeper: An Entrance Control System Embedded Radiation Detection Capability for Security Applications. [PDF]
Sensors (Basel), 2020 Martin PG +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Technological Capability and Productivity Growth: An Industrialized / Industrializing Country Comparison [PDF]
The importance of technical change as a crucial element explaining inter-country differences in levels and rates of change in industrial productivity has been increasingly acknowledged.
Pierre J. Tremblay
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Colorimetric mercury detection with enhanced sensitivity using magnetic-Au hybrid nanoparticles. [PDF]
Nanoscale Adv, 2023 Jeong M, Bae D, Choi JS.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Measuring Regional Innovative Capability [PDF]
Regional innovation environment has experienced remarkable changes in the recent decades. Innovativeness at regional level is seen as a consequence of networked co-operation in a regional innovation system, which sets demands for new kinds of regional ...
Vesa Harmaakorpi, Tomi Tura
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