Results 151 to 160 of about 3,842,363 (279)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Tightly Coupled GNSS/IMU Hybrid Navigation Using Factor Graph Optimization with NLOS Detection Capability. [PDF]
Sensors (Basel)Tanimura H, Tsujii T.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Valuing the Environment in a Diverse World
, 2011 What challenge does the diversity of values – when we are dealing with the environment – pose? More specifically, can the capability approach – given its claim to accommodate widespread cultural differences – take on board the different ways in which we ...
Watene, Krushil
core
Investigation of the Impact of Extraneous Odours on the Detection Capability of Explosive Detection Dogs Under a Controlled Test Environment. [PDF]
Animals (Basel)Becher C +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Capability Modeling: Initial Experiences
Enterprises operate in dynamically changing environments, consequently, information systems (IS) are a subject to continuous changes. The IS need to be adjusted to different customers, markets and run-time contexts affecting their design and delivery ...
Grabis, Jānis +6 more
core
LA-EAD: Simple and Effective Methods for Improving Logical Anomaly Detection Capability. [PDF]
Sensors (Basel)Li Z, Yang Z, Zhang L, Yang L, Liu J.
europepmc +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Boosting CRISPR/Cas12a intrinsic RNA detection capability through pseudo hybrid DNA-RNA substrate design. [PDF]
Nucleic Acids ResQiao J +6 more
europepmc +1 more source