Results 151 to 160 of about 3,695,100 (289)

Sensitivity and specificity of in vivo COVID-19 screening by detection dogs: Results of the C19-Screendog multicenter study. [PDF]

Heliyon, 2023
Soggiu F, Sabbatinelli J, Giuliani A, Benedetti R, Marchegiani A, Sgarangella F, Tibaldi A, Corsi D, Procopio AD, Calgaro S, Olivieri F, Spaterna A, Zampieri R, Rippo MR, C19-Screendog study group.   +14 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time? [PDF]

Appl Anim Behav Sci, 2023
Ozgur-Buyukatalay E, Demirbas YS, Bozdayi G, Kismali G, Ilhan MN.   +4 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Development of a safety protocol for training and using SARS-CoV-2 detection dogs: A pilot study. [PDF]

J Vet Behav, 2023
Demirbas YS, Kismali G, Saral B, Sareyyupoglu B, Habiloglu AD, Ozturk H, Bas B, Ozvardar T, Alpay M, Ince N, Canbay H, Emen F, At Lgan D, Isparta S, Ozgur E, Sahin I, Pereira GADGA, Ozkul A.   +17 more
europepmc   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Use of narcotics detection dogs

, 1998
"October 7, 1998."; Discusses when police can use narcotics detection dogs to conduct searches on school grounds, whether schools have to have a policy on their use, and, whether there are any court cases specifically on ...
Norman-Eady, Sandra,
core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Predicting missed alerts in detection dogs. [PDF]

Sci Rep
Schultz J, Rothkoff L, Aviles-Rosa EO, Hall NJ, Maughan MN.   +4 more
europepmc   +1 more source