Results 51 to 60 of about 240,773 (297)

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]

, 2020
COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin, Araujo, Joseph, De Lannoy, Ines AM, Dominy, Stephen S, Ermini, Florian, Haditsch, Ursula, Holsinger, Leslie J, Lynch, Casey, Nguyen, Mai, Raha, Debasish, Ryder, Mark I   +10 more
core   +1 more source

Detection dog survey detects African wild dog presence and a shared marking site

Ecology and Evolution
ABSTRACTAfrican wild dog (Lycaon pictus) populations are difficult to assess effectively and scalable strategies for population monitoring are lacking, often because of low detection rates. Scat detection dogs (Canis lupus familiaris) have emerged as a suitable tool to detect the presence of wide‐ranging carnivores.
Tim Hofmann, Stijn Verschueren, Tresia Shihepo, Bogdan Cristescu, Nicole Anderson, Nadja le Roux, Shweta Singh, Stephan Neumann, Niko Balkenhol, Laurie Marker, Anne Schmidt‐Küntzel   +10 more
openaire   +4 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Exploring the potential role of built environments in wildlife conservation during wildfires

Conservation Science and Practice
As the frequency and severity of wildfires continue to rise, fire refugia could play a critical role in reducing impacts on affected wildlife species.
Katrin Hohwieler, Carmen Piza Roca, Elizabeth Brunton, Michelle Ward, Romane H. Cristescu   +4 more
doaj   +1 more source

Environmental determinants of landmine detection by dogs: Findings from a large-scale study in Afghanistan [PDF]

, 2012
This article’s purpose is to examine the strengths and weaknesses of mine-detection dogs in different environments. The experiments employed a total of 39 dogs in Afghanistan between October 2002 and July 2003.
Bach, Havard, Brown, Jennifer, McLean, Ian G., Sargisson, Rebecca J.   +3 more
core   +2 more sources

Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england [PDF]

, 2015
Background To date, epidemiological studies on degenerative mitral valve disease (DMVD) in dogs have largely reported referral caseloads or been limited to predisposed breeds.
Bavegems, Borgarelli, Borgarelli, Borgarelli, Buchanan, Bussadori, Chetboul, Darke, Das, Detweiler, Dohoo, Egenvall, Fabrizio, Haggstrom, Heinze, Jones, Kearsley-Fleet, Lundin, Mattin, O'Neill, Olsen, Olsen, Parker, Pedersen, Pfeiffer, Serfass, Slater, StataCorp, Thrusfield, Whitney   +29 more
core   +3 more sources

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Two Species of Canine Babesia in Australia: Detection and Characterization by PCR [PDF]

, 2003
The haemoprotozoan Babesia canis has been recognized in Australia for many years, and a second, smaller species has recently been discovered. Amplification and sequencing of a partial region of the 18S small subunit ribosomal RNA (rRNA) gene enabled ...
Irwin, P.J., Jefferies, R., Muhlnickel, C.J., Ryan, U.   +3 more
core   +2 more sources

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Noninvasive techniques provide novel insights for the elusive bush dog (Speothos venaticus)

Wildlife Society Bulletin, 2014
The bush dog (Speothos venaticus), a small and rarely seen canid from Central and South America, has proven extremely challenging to locate and study in the wild, making the development of species‐specific and comprehensive carnivore conservation ...
Karen E. DEMatteo, Miguel A. Rinas, Carina F. Argüelles, Juan Pablo Zurano, Nicole Selleski, Mario S. Di Bitetti, Lori S. Eggert   +6 more
doaj   +1 more source