Results 91 to 100 of about 2,243,348 (294)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Sample Efficient Approaches for Idiomaticity Detection

, 2022
Deep neural models, in particular Transformer-based pre-trained language models, require a significant amount of data to train. This need for data tends to lead to problems when dealing with idiomatic multiword expressions (MWEs), which are inherently less frequent in natural text.
Phelps, D., Fan, X.-R., Gow-Smith, E., Madabushi, H.T., Scarton, C., Villavicencio, A.   +5 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Single-Shot Refinement Neural Network for Object Detection

, 2018
For object detection, the two-stage approach (e.g., Faster R-CNN) has been achieving the highest accuracy, whereas the one-stage approach (e.g., SSD) has the advantage of high efficiency. To inherit the merits of both while overcoming their disadvantages,
Bian, Xiao, Lei, Zhen, Li, Stan Z., Wen, Longyin, Zhang, Shifeng   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Determination of Gross Beta Activity Excluding 40K in Seawater Around Nuclear Power Plant by Cobalt Sulfide Coprecipitation Method

Yuanzineng kexue jishu, 2022
In order to simply, quickly and efficiently evaluate the impact of nuclear power plant operation on the surrounding marine environment, a cobalt sulfide coprecipitation method was established to rapidly analyze the gross beta activity excluding 40K in ...
WU Liansheng;HE Yi;SUN Xuefeng;HUANG Yanjun;LI Yuan;LIU Tao;ZENG Fan;CHEN Chaofeng;SHANGGUAN Zhihong;YANG Ziqian
doaj  

Direct measurement of the Wigner function by photon-number-resolving detection

, 2014
Photon-number-revolving (PNR) detection allows the direct measurement of the Wigner quasiprobability distribution of an optical mode without the need for numerically processing an inverse Radon transform [K. Banaszek and K. W\'odkiewicz, Phys. Rev. Lett.
Calkins, Brice, Gerrits, Thomas, Lita, Adriana, Miller, Aaron J., Nam, Sae Woo, Pfister, Olivier, Shahrokhshahi, Reihaneh, Sridhar, Niranjan   +7 more
core   +1 more source

Space-Efficient Detection of Unusual Words [PDF]

, 2015
Detecting all the strings that occur in a text more frequently or less frequently than expected according to an IID or a Markov model is a basic problem in string mining, yet current algorithms are based on data structures that are either space-inefficient or incur large slowdowns, and current implementations cannot scale to genomes or metagenomes in ...
Belazzougui, D., Cunial, F.
openaire   +3 more sources